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10.1002/sctm.17-0186 http://scihub22266oqcxt.onion/10.1002/sctm.17-0186 C5905229!5905229!29446551     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Stem+Cells+Transl+Med 2018 ; 7 (5): 394-403 Nephropedia Template TP {{tp|p=29446551|t=2018. Targeting Murine Mesenchymal Stem Cells to Kidney Injury Molecule?1 Improves Their Therapeutic Efficacy in Chronic Ischemic Kidney Injury |pdf=|usr=}}{{29446551}} gab.com Text Targeting Murine Mesenchymal Stem Cells to Kidney Injury Molecule 1 Improves Their Therapeutic Efficacy in Chronic Ischemic Kidney Injury JO: Stem Cells Transl Med http://www.kidney.de/pget.php?&tw=1&pmid=29446551 #FOAvip Mesenchymal stem cells (MSC) have been experimentally used for kidney repair, but modest retention limits their efficacy. Cell?surface coating allows modulating MSC homing and interaction with target cells. We coated mouse adipose tissue?derived MSC with antibodies directed against kidney injury molecule?1 (ab?KIM1), which is upregulated in injured kidneys, and tested the hypothesis that this would enhance their therapeutic effects in ischemic kidney injury. Untreated MSC, ab?KIM1?coated MSC (KIM?MSC), or vehicle, were injected systemically into the carotid artery of 2?kidneys, 1?clip mice 2 weeks after surgery. MSC retention in different organs was explored 24 hours, 48 hours, or 2 weeks after injection. Renal volume, perfusion, and oxygenation were studied 2 weeks after injection using magnetic resonance imaging in vivo, and renal inflammation, apoptosis, capillary density, and fibrosis ex vivo. The ab?KIM1 coating had little effect on MSC viability or proliferation. The stenotic kidney showed upregulated KIM1 expression, selective homing, and greater retention of KIM?MSC compared to untreated MSC and compared to other organs. KIM?MSC?injected mice improved renal perfusion and capillary density, and attenuated oxidative damage, apoptosis, and fibrosis compared to mice treated with vehicle or with native MSC. In conclusion, MSC coating with ab?KIM1 increased their retention in the ischemic kidney and enhanced their therapeutic efficacy. This novel method may be useful to selectively target injured kidneys, and supports further development of strategies to enhance cell?based treatment of ischemic kidney injury. Stem Cells Translational Medicine2018;7:394?403 Twit Text FOAVip Targeting Murine Mesenchymal Stem Cells to Kidney Injury Molecule 1 Improves Their Therapeutic Efficacy in Chronic Ischemic Kidney Injury ????Stem Cells Transl Med http://www.kidney.de/pget.php?&tw=1&pmid=29446551 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29446551 #FOAvip English Wikipedia <ref>{{Cite pmid|29446551}}</ref> Targeting Murine Mesenchymal Stem Cells to Kidney Injury Molecule?1 Improves Their Therapeutic Efficacy in Chronic Ischemic Kidney Injury #MMPMID29446551 Zou X; Jiang K; Puranik AS; Jordan KL; Tang H; Zhu X; Lerman LO Stem Cells Transl Med 2018[May]; 7 (5): 394-403 PMID29446551show ga Mesenchymal stem cells (MSC) have been experimentally used for kidney repair, but modest retention limits their efficacy. Cell?surface coating allows modulating MSC homing and interaction with target cells. We coated mouse adipose tissue?derived MSC with antibodies directed against kidney injury molecule?1 (ab?KIM1), which is upregulated in injured kidneys, and tested the hypothesis that this would enhance their therapeutic effects in ischemic kidney injury. Untreated MSC, ab?KIM1?coated MSC (KIM?MSC), or vehicle, were injected systemically into the carotid artery of 2?kidneys, 1?clip mice 2 weeks after surgery. MSC retention in different organs was explored 24 hours, 48 hours, or 2 weeks after injection. Renal volume, perfusion, and oxygenation were studied 2 weeks after injection using magnetic resonance imaging in vivo, and renal inflammation, apoptosis, capillary density, and fibrosis ex vivo. The ab?KIM1 coating had little effect on MSC viability or proliferation. The stenotic kidney showed upregulated KIM1 expression, selective homing, and greater retention of KIM?MSC compared to untreated MSC and compared to other organs. KIM?MSC?injected mice improved renal perfusion and capillary density, and attenuated oxidative damage, apoptosis, and fibrosis compared to mice treated with vehicle or with native MSC. In conclusion, MSC coating with ab?KIM1 increased their retention in the ischemic kidney and enhanced their therapeutic efficacy. This novel method may be useful to selectively target injured kidneys, and supports further development of strategies to enhance cell?based treatment of ischemic kidney injury. Stem Cells Translational Medicine2018;7:394?403 äTargeting Murine Mesenchymal Stem Cells to Kidney Injury Molecule?1 Im(epmc).pdf DeepDyve Pubget Overpricing