Transcription fidelity and its roles in the cell #MMPMID28968546
Gamba P; Zenkin N
Curr Opin Microbiol 2018[Apr]; 42 (ä): 13-8 PMID28968546show ga
?The Trigger Loop is one of the major determinants of transcription fidelity.?Intrinsic proofreading occurs via transcript-assisted cleavage.?Factor-assisted proofreading takes place via exchange of RNAP active centres.?Misincorporation is a major source of transcription pausing.?Another role of fidelity is the prevention of conflicts with other cellular processes.