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Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Acta+Neuropathol 2018 ; 135 (5): 671-9 Nephropedia Template TP
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Evidence of amyloid-? cerebral amyloid angiopathy transmission through neurosurgery #MMPMID29450646
Jaunmuktane Z; Quaegebeur A; Taipa R; Viana-Baptista M; Barbosa R; Koriath C; Sciot R; Mead S; Brandner S
Acta Neuropathol 2018[]; 135 (5): 671-9 PMID29450646show ga
Amyloid-? (A?) is a peptide deposited in the brain parenchyma in Alzheimer?s disease and in cerebral blood vessels, causing cerebral amyloid angiopathy (CAA). A? pathology is transmissible experimentally in animals and through medical procedures in humans, such as contaminated growth hormone or dura mater transplantation in the context of iatrogenic prion disease. Here, we present four patients who underwent neurosurgical procedures during childhood or teenage years and presented with intracerebral haemorrhage approximately three decades later, caused by severe CAA. None of these patients carried pathogenic mutations associated with early A? pathology development. In addition, we identified in the literature four patients with a history of neurosurgical intervention and subsequent development of CAA. These findings raise the possibility that A? pathology may be transmissible, as prion disease is, through neurosurgical procedures.Electronic supplementary material: The online version of this article (10.1007/s00401-018-1822-2) contains supplementary material, which is available to authorized users.