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10.1016/j.tmrv.2015.08.002 http://scihub22266oqcxt.onion/10.1016/j.tmrv.2015.08.002 C5903434!5903434!26341586     free     free     free       Transfus+Med+Rev 2015 ; 29 (4): 215-9 Nephropedia Template TP {{tp|p=26341586|t=2015. Platelet MicroRNAs: An Overview |pdf=|usr=}}{{26341586}} gab.com Text Platelet MicroRNAs: An Overview JO: Transfus Med Rev http://www.kidney.de/pget.php?&tw=1&pmid=26341586 #FOAvip MicroRNAs (miRNAs) are short ~22-nucleotide noncoding RNA that have been found to influence the expression of many genes and cellular processes by either repressing translation or degrading messenger RNA transcripts. Platelet miRNA expression has been shown to be perturbed during ex vivo storage of platelets and in platelet-associated disorders. Although bioinformatics-based miRNA target predictions have been established, direct experimental validation of the role of miRNAs in platelet biology has been rather slow. Target prediction studies are, nonetheless, valuable in directing the design of appropriate experiments to test specific miRNA:messenger RNA interactions relevant to the underlying mechanisms of platelet function in general and in disease as well as in ex vivo storage-associated ?storage lesions,? a collective term used to include physiologic, biochemical, and morphologic changes that occur in stored platelets. This brief review will focus on emerging human platelet miRNA studies to emphasize their potential role relevant to transfusion medicine field in terms of regulating platelet signaling pathways, markers of platelet associated disorders, and remote impactors of gene expression (intercellular biomodulators) as well as potential platelet quality markers of storage and pathogen reduction treatments. Twit Text FOAVip Platelet MicroRNAs: An Overview ????Transfus Med Rev http://www.kidney.de/pget.php?&tw=1&pmid=26341586 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26341586 #FOAvip English Wikipedia <ref>{{Cite pmid|26341586}}</ref> Platelet MicroRNAs: An Overview #MMPMID26341586 Dahiya N; Sarachana T; Vu L; Becker KG; Wood WH; Zhang Y; Atreya CD Transfus Med Rev 2015[Oct]; 29 (4): 215-9 PMID26341586show ga MicroRNAs (miRNAs) are short ~22-nucleotide noncoding RNA that have been found to influence the expression of many genes and cellular processes by either repressing translation or degrading messenger RNA transcripts. Platelet miRNA expression has been shown to be perturbed during ex vivo storage of platelets and in platelet-associated disorders. Although bioinformatics-based miRNA target predictions have been established, direct experimental validation of the role of miRNAs in platelet biology has been rather slow. Target prediction studies are, nonetheless, valuable in directing the design of appropriate experiments to test specific miRNA:messenger RNA interactions relevant to the underlying mechanisms of platelet function in general and in disease as well as in ex vivo storage-associated ?storage lesions,? a collective term used to include physiologic, biochemical, and morphologic changes that occur in stored platelets. This brief review will focus on emerging human platelet miRNA studies to emphasize their potential role relevant to transfusion medicine field in terms of regulating platelet signaling pathways, markers of platelet associated disorders, and remote impactors of gene expression (intercellular biomodulators) as well as potential platelet quality markers of storage and pathogen reduction treatments. äPlatelet MicroRNAs: An Overview (epmc).pdf DeepDyve Pubget Overpricing