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2017 ; 7
(6
): e60561
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gab.com Text
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English Wikipedia
Acute Pain Management in Emergency Department, Low Dose Ketamine Versus Morphine,
A Randomized Clinical Trial
#MMPMID29696126
Mahshidfar B
; Mofidi M
; Fattahi M
; Farsi D
; Hafezi Moghadam P
; Abbasi S
; Rezai M
Anesth Pain Med
2017[Dec]; 7
(6
): e60561
PMID29696126
show ga
BACKGROUND: Ketamine, as an opium alternative, has been proposed for pain relief
in the emergency department (ED). OBJECTIVES: This study was carried out to
compare low dose ketamine (LDK) with morphine for pain relief in trauma patients.
METHODS: In this randomized double-blinded clinical trial, 300 trauma patients
from the ED of 2 teaching hospitals in Tehran, Iran were enrolled and randomly
divided into 2 equal groups. The 1st group received 0.2 mg/kg of ketamine while
the 2nd group received 0.1 mg/kg of intravenous morphine. The pain intensity and
complications were measured and compared every 15 minutes to 1 hour. RESULTS:
Fifteen minutes after drug injection in both groups, a significant reduction was
found in average pain intensity compared to the initial pain (P = 0.01). At 15
minutes, no significant difference was found in both groups in regards to average
pain intensity (P = 0.23). The average pain intensity at 30, 45, and 60 minutes
in the group receiving morphine was lower than the ketamine group (P = 0.01, P <
0.001, P < 0.001 respectively). Two complications (drop in O(2) saturation below
90% and flushing) were significantly greater in the morphine group. CONCLUSIONS:
The results of this study suggest that LDK, at a dose of 0.2 mg/kg, in the
earlier minutes leads to significant reduction of pain when compared to that of
intravenous morphine. It also created fewer complications than morphine.