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Assessment of Vitamin D-Binding Protein and Early Prediction of Nephropathy in
Type 2 Saudi Diabetic Patients
#MMPMID29850609
Fawzy MS
; Abu AlSel BT
J Diabetes Res
2018[]; 2018
(?): 8517929
PMID29850609
show ga
Early detection of diabetic nephropathy (DN) represents a great challenge in an
attempt to reduce the burden of chronic kidney diseases in diabetic patients.
This study aimed to investigate the potential early prediction role of urinary
vitamin D-binding protein (uVDBP) for the diagnosis of DN and to examine the
possible correlation to serum VDBP, high-sensitivity C-reactive protein (hs-CRP),
and insulin resistance in these patients. Serum and urine samples were obtained
from 40 healthy volunteers and 120 patients with type 2 diabetes divided into 3
groups: normoalbuminuria, microalbuminuria, and macroalbuminuria (urinary albumin
excretion rate?300??g/mg, resp.); n = 40/group. Serum and
urinary VDBP levels were quantified by ELISA. Insulin resistance has been
assessed by homeostasis model assessment index (HOMAI). Correction for urine
creatinine concentration was applied for urinary quantitative measurements. uVDBP
levels were significantly elevated in micro- and macroalbuminuria patient groups
compared with those of the normoalbuminuria patient group and controls
(820.4?±?402.8 and 1458.1?±?210.0 compared with 193.1?±?141.0 and
127.7?±?21.9?ng/mg, resp.) (P < 0.001). There was significant correlation between
serum and urinary levels of VDBP in total patient group. Receiver operating
characteristic analysis of uVDBP levels showed optimum cut-off value of
216.0?ng/mg corresponding to 98.8% sensitivity and 80.0% specificity and an area
under the curve of 0.973 to discriminate the normoalbuminuria from the
microalbuminuria groups. In multivariate analysis, ordination plot showed obvious
demarcation between the study groups caused by the higher levels of uVDBP and
albumin/creatinine ratio among other variables. The study findings suggested a
possible clinical application of uVDPB as an early and a good marker for the
detection of early renal disease in type 2 DM Saudi patients. Large-scale
validation studies are warranted to confirm the results before including uVDBP
with the available list of other conventional biomarkers.
|Adult
[MESH]
|Albuminuria/blood/*diagnosis/urine
[MESH]
|Biomarkers/metabolism
[MESH]
|Diabetes Mellitus, Type 2/blood/*metabolism/urine
[MESH]
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