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Megavoltage Radiotherapy for the Treatment of Degenerative Joint Disease in Dogs:
Results of a Preliminary Experience in an Italian Radiotherapy Centre
#MMPMID29692993
Rossi F
; Cancedda S
; Leone VF
; Rohrer Bley C
; Laganga P
Front Vet Sci
2018[]; 5
(?): 74
PMID29692993
show ga
The aim of the study was to evaluate the efficacy and toxicity of a low-dose
radiotherapy treatment in dogs with osteoarthritis (OA). Inclusion criteria were
dogs affected by OA of one or multiple joints, with lameness, previously treated
with medical therapy and referred for radiotherapy because of chronic
unresponsive pain. After suspension of medical therapy, dogs underwent external
beam radiotherapy treatments delivered in three fractions of 2?Gy each. Four of
these dogs had one (three dogs) to four (one dog) additional courses of
radiation. Medical records were reviewed and follow-up information was collected
by clinical recheck and owners interview. Twenty-five dogs matched the inclusion
criteria; among them, 21 had one course of RT and 4 underwent multiple
treatments, respectively 218, 266, 39, and 1,384?days after the first treatment.
Clinical improvement was observed in 92% of patients with median benefit duration
of 356?days after the first treatment, and 418?days after the second treatment.
No side effects were recorded. In this group of patients, radiotherapy was
effective, well tolerated, and repeatable, leading to an improvement of quality
of life in dogs with degenerative joint disease unresponsive to medical
treatments.
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