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10.1021/acsinfecdis.7b00231 http://scihub22266oqcxt.onion/10.1021/acsinfecdis.7b00231 C5902792!5902792!29465983     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       ACS+Infect+Dis 2018 ; 4 (4): 478-98 Nephropedia Template TP {{tp|p=29465983|t=2018. Targeting the Proteostasis Network for Mycobacterial Drug Discovery |pdf=|usr=}}{{29465983}} gab.com Text Targeting the Proteostasis Network for Mycobacterial Drug Discovery JO: ACS Infect Dis http://www.kidney.de/pget.php?&tw=1&pmid=29465983 #FOAvip Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), remains one of the world?s deadliest infectious diseases and urgently requires new antibiotics to treat drug-resistant strains and to decrease the duration of therapy. During infection, Mtb encounters numerous stresses associated with host immunity, including hypoxia, reactive oxygen and nitrogen species, mild acidity, nutrient starvation, and metal sequestration and intoxication. The Mtb proteostasis network, composed of chaperones, proteases, and a eukaryotic-like proteasome, provides protection from stresses and chemistries of host immunity by maintaining the integrity of the mycobacterial proteome. In this Review, we explore the proteostasis network as a noncanonical target for antibacterial drug discovery. Twit Text FOAVip Targeting the Proteostasis Network for Mycobacterial Drug Discovery ????ACS Infect Dis http://www.kidney.de/pget.php?&tw=1&pmid=29465983 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29465983 #FOAvip English Wikipedia <ref>{{Cite pmid|29465983}}</ref> Targeting the Proteostasis Network for Mycobacterial Drug Discovery #MMPMID29465983 Lupoli TJ; Vaubourgeix J; Burns-Huang K; Gold B ACS Infect Dis 2018[Apr]; 4 (4): 478-98 PMID29465983show ga Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), remains one of the world?s deadliest infectious diseases and urgently requires new antibiotics to treat drug-resistant strains and to decrease the duration of therapy. During infection, Mtb encounters numerous stresses associated with host immunity, including hypoxia, reactive oxygen and nitrogen species, mild acidity, nutrient starvation, and metal sequestration and intoxication. The Mtb proteostasis network, composed of chaperones, proteases, and a eukaryotic-like proteasome, provides protection from stresses and chemistries of host immunity by maintaining the integrity of the mycobacterial proteome. In this Review, we explore the proteostasis network as a noncanonical target for antibacterial drug discovery. äTargeting the Proteostasis Network for Mycobacterial Drug Discovery (epmc).pdf DeepDyve Pubget Overpricing