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10.1038/pr.2017.290 http://scihub22266oqcxt.onion/10.1038/pr.2017.290 C5902650!5902650!29166383     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 296.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 296.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Pediatr+Res 2018 ; 83 (3): 702-11 Nephropedia Template TP {{tp|p=29166383|t=2018. Prematurity Disrupts Glomeruli Development while Prematurity and Hyperglycemia Lead to Altered Nephron Maturation and Increased Oxidative Stress in Newborn Baboons |pdf=|usr=}}{{29166383}} gab.com Text Prematurity Disrupts Glomeruli Development while Prematurity and Hyperglycemia Lead to Altered Nephron Maturation and Increased Oxidative Stress in Newborn Baboons JO: Pediatr Res http://www.kidney.de/pget.php?&tw=1&pmid=29166383 #FOAvip Background: Premature birth occurs when nephrogenesis is incomplete and has been linked to increased renal pathologies in the adult. Metabolic factors complicating preterm birth may have additional consequences for kidney development. Here, we evaluated the effects of prematurity and hyperglycemia on nephrogenesis in premature baboons when compared to term animals. Methods: Baboons were delivered prematurely (67% gestation; n=9) or at term (n=7) and survived 2?4 weeks. Preterm animals were classified by glucose control during the first five days of life (DOL): normoglycemic (PtN; serum glucose 50?100mg/dL, n=6) and hyperglycemic (PtH; serum glucose 150?250mg/dL, n=3). Kidneys were assessed histologically for glomeruli relative area, maturity, size, and overall morphology. Kidney lysates were evaluated for oxidative damage with 4-hydroxynonenal (4-HNE) antibody. Results: Histological examination revealed decreased glomeruli relative area (p<0.05), fewer glomerular generations (p<0.01), and increased renal corpuscle area (p<0.001) in preterm compared to term animals. Numbers of apoptotic glomeruli were similar between groups. PtH kidneys exhibited reduced nephrogenic zone width (p<0.0001), increased numbers of mature glomeruli (p<0.05), and increased 4-HNE staining compared to PtN kidneys. Conclusion: Prematurity interrupts normal kidney development, independent of glomerular cell apoptosis. When prematurity is complicated by hyperglycemia; kidney development shifts towards accelerated maturation and increased oxidative stress. Twit Text FOAVip Prematurity Disrupts Glomeruli Development while Prematurity and Hyperglycemia Lead to Altered Nephron Maturation and Increased Oxidative Stress in Newborn Baboons ????Pediatr Res http://www.kidney.de/pget.php?&tw=1&pmid=29166383 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29166383 #FOAvip English Wikipedia <ref>{{Cite pmid|29166383}}</ref> Prematurity Disrupts Glomeruli Development while Prematurity and Hyperglycemia Lead to Altered Nephron Maturation and Increased Oxidative Stress in Newborn Baboons #MMPMID29166383 Callaway DA; McGill-Vargas LL; Quinn A; Jordan JL; Winter LA; Anzueto D; Dick EJ; Blanco CL Pediatr Res 2018[Mar]; 83 (3): 702-11 PMID29166383show ga Background: Premature birth occurs when nephrogenesis is incomplete and has been linked to increased renal pathologies in the adult. Metabolic factors complicating preterm birth may have additional consequences for kidney development. Here, we evaluated the effects of prematurity and hyperglycemia on nephrogenesis in premature baboons when compared to term animals. Methods: Baboons were delivered prematurely (67% gestation; n=9) or at term (n=7) and survived 2?4 weeks. Preterm animals were classified by glucose control during the first five days of life (DOL): normoglycemic (PtN; serum glucose 50?100mg/dL, n=6) and hyperglycemic (PtH; serum glucose 150?250mg/dL, n=3). Kidneys were assessed histologically for glomeruli relative area, maturity, size, and overall morphology. Kidney lysates were evaluated for oxidative damage with 4-hydroxynonenal (4-HNE) antibody. Results: Histological examination revealed decreased glomeruli relative area (p<0.05), fewer glomerular generations (p<0.01), and increased renal corpuscle area (p<0.001) in preterm compared to term animals. Numbers of apoptotic glomeruli were similar between groups. PtH kidneys exhibited reduced nephrogenic zone width (p<0.0001), increased numbers of mature glomeruli (p<0.05), and increased 4-HNE staining compared to PtN kidneys. Conclusion: Prematurity interrupts normal kidney development, independent of glomerular cell apoptosis. When prematurity is complicated by hyperglycemia; kidney development shifts towards accelerated maturation and increased oxidative stress. äPrematurity Disrupts Glomeruli Development while Prematurity and Hyper(epmc).pdf DeepDyve Pubget Overpricing