Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29692756
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29692756
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Front+Neurol
2018 ; 9
(ä): 244
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Hierarchical Cluster Analysis of Semicircular Canal and Otolith Deficits in
Bilateral Vestibulopathy
#MMPMID29692756
Tarnutzer AA
; Bockisch CJ
; Buffone E
; Weber KP
Front Neurol
2018[]; 9
(ä): 244
PMID29692756
show ga
BACKGROUND: Gait imbalance and oscillopsia are frequent complaints of bilateral
vestibular loss (BLV). Video-head-impulse testing (vHIT) of all six semicircular
canals (SCCs) has demonstrated varying involvement of the different canals.
Sparing of anterior-canal function has been linked to aminoglycoside-related
vestibulopathy and Menière's disease. We hypothesized that utricular and saccular
impairment [assessed by vestibular-evoked myogenic potentials (VEMPs)] may be
disease-specific also, possibly facilitating the differential diagnosis. METHODS:
We searched our vHIT database (n?=?3,271) for patients with bilaterally impaired
SCC function who also received ocular VEMPs (oVEMPs) and cervical VEMPs (cVEMPs)
and identified 101 patients. oVEMP/cVEMP latencies above the 95th percentile and
peak-to-peak amplitudes below the 5th percentile of normal were considered
abnormal. Frequency of impairment of vestibular end organs
(horizontal/anterior/posterior SCC, utriculus/sacculus) was analyzed with
hierarchical cluster analysis and correlated with the underlying etiology.
RESULTS: Rates of utricular and saccular loss of function were similar (87.1 vs.
78.2%, p?=?0.136, Fisher's exact test). oVEMP abnormalities were found more
frequent in aminoglycoside-related bilateral vestibular loss (BVL) compared with
Menière's disease (91.7 vs. 54.6%, p?=?0.039). Hierarchical cluster analysis
indicated distinct patterns of vestibular end-organ impairment, showing that the
results for the same end-organs on both sides are more similar than to other
end-organs. Relative sparing of anterior-canal function was reflected in late
merging with the other end-organs, emphasizing their distinct state. An
anatomically corresponding pattern of SCC/otolith hypofunction was present in
60.4% (oVEMPs vs. horizontal SCCs), 34.7% (oVEMPs vs. anterior SCCs), and 48.5%
(cVEMPs vs. posterior SCCs) of cases. Average (±1 SD) number of damaged sensors
was 6.8?±?2.2 out of 10. Significantly (p?
free
free
free
