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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 PLoS+One
2018 ; 13
(4
): e0195730
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Humoral immunity to memory antigens and pathogens is maintained in patients with
chronic kidney disease
#MMPMID29659606
Wall NA
; Dominguez-Medina CC
; Faustini SE
; Cook CN
; McClean A
; Jesky MD
; Perez-Toledo M
; Morgan MD
; Richter AG
; Ferro CJ
; Cockwell P
; Moss PA
; Henderson IR
; Harper L
; Cunningham AF
PLoS One
2018[]; 13
(4
): e0195730
PMID29659606
show ga
Patients with chronic kidney disease (CKD) have an increased risk of infection
and poorer responses to vaccination. This suggests that CKD patients have an
impaired responsiveness to all antigens, even those first encountered before CKD
onset. To examine this we evaluated antibody responses against two childhood
vaccine antigens, tetanus (TT) and diphtheria toxoids (DT) and two common
pathogens, cytomegalovirus (CMV) and Salmonella enterica serovar Enteritidis
(SEn) in two independent cohorts consisting of age-matched individuals with and
without CKD. Sera were evaluated for antigen-specific IgG titres and the
functionality of antibody to SEn was assessed in a serum bactericidal assay.
Surprisingly, patients with CKD and control subjects had comparable levels of IgG
against TT and DT, suggesting preserved humoral memory responses to antigens
encountered early in life. Lipopolysaccharide-specific IgG titres and serum
bactericidal activity in patients with CKD were also not inferior to controls.
CMV-specific IgG titres in seropositive CKD patients were similar or even
increased compared to controls. Therefore, whilst responses to new vaccines in
CKD are typically lower than expected, antibody responses to antigens commonly
encountered prior to CKD onset are not. The immunodeficiency of CKD is likely
characterised by failure to respond to new antigenic challenges and efforts to
improve patient outcomes should be focussed here.
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