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10.1038/labinvest.2017.29 http://scihub22266oqcxt.onion/10.1038/labinvest.2017.29 C5901959!5901959 !28581486     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28581486 &cmd=llinks): Failed to open stream: HTTP request failed! 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The Hippo signaling functions through the Notch signaling to regulate intrahepatic bile duct development in mammals |pdf=|usr=}}{{28581486 }} gab.com Text The Hippo signaling functions through the Notch signaling to regulate intrahepatic bile duct development in mammals JO: Lab Invest http://www.kidney.de/pget.php?&tw=1&pmid=28581486 #FOAvip The Hippo signaling pathway and the Notch signaling pathway are evolutionary conserved signaling cascades that have important roles in embryonic development of many organs. In murine liver, disruption of either pathway impairs intrahepatic bile duct development. Recent studies suggested that the Notch signaling receptor Notch2 is a direct transcriptional target of the Hippo signaling pathway effector YAP, and the Notch signaling is a major mediator of the Hippo signaling in maintaining biliary cell characteristics in adult mice. However, it remains to be determined whether the Hippo signaling pathway functions through the Notch signaling in intrahepatic bile duct development. We found that loss of the Hippo signaling pathway tumor suppressor Nf2 resulted in increased expression levels of the Notch signaling pathway receptor Notch2 in cholangiocytes but not in hepatocytes. When knocking down Notch2 on the background of Nf2 deficiency in mouse livers, the excessive bile duct development induced by Nf2 deficiency was suppressed by heterozygous and homozygous deletion of Notch2 in a dose-dependent manner. These results implicated that Notch signaling is one of the downstream effectors of the Hippo signaling pathway in regulating intrahepatic bile duct development. Twit Text FOAVip The Hippo signaling functions through the Notch signaling to regulate intrahepatic bile duct development in mammals ????Lab Invest http://www.kidney.de/pget.php?&tw=1&pmid=28581486 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28581486 #FOAvip English Wikipedia <ref>{{Cite pmid|28581486 }}</ref> The Hippo signaling functions through the Notch signaling to regulate intrahepatic bile duct development in mammals #MMPMID28581486 Wu N ; Nguyen Q ; Wan Y ; Zhou T ; Venter J ; Frampton GA ; DeMorrow S ; Pan D ; Meng F ; Glaser S ; Alpini G ; Bai H Lab Invest 2017[Jul]; 97 (7 ): 843-853 PMID28581486 show ga The Hippo signaling pathway and the Notch signaling pathway are evolutionary conserved signaling cascades that have important roles in embryonic development of many organs. In murine liver, disruption of either pathway impairs intrahepatic bile duct development. Recent studies suggested that the Notch signaling receptor Notch2 is a direct transcriptional target of the Hippo signaling pathway effector YAP, and the Notch signaling is a major mediator of the Hippo signaling in maintaining biliary cell characteristics in adult mice. However, it remains to be determined whether the Hippo signaling pathway functions through the Notch signaling in intrahepatic bile duct development. We found that loss of the Hippo signaling pathway tumor suppressor Nf2 resulted in increased expression levels of the Notch signaling pathway receptor Notch2 in cholangiocytes but not in hepatocytes. When knocking down Notch2 on the background of Nf2 deficiency in mouse livers, the excessive bile duct development induced by Nf2 deficiency was suppressed by heterozygous and homozygous deletion of Notch2 in a dose-dependent manner. These results implicated that Notch signaling is one of the downstream effectors of the Hippo signaling pathway in regulating intrahepatic bile duct development. |Animals [MESH] |Bile Ducts, Intrahepatic/*growth & development/metabolism/pathology [MESH] |Female [MESH] |Hippo Signaling Pathway [MESH] |Male [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Mice, Knockout [MESH] |Neurofibromatosis 2/genetics/*metabolism [MESH] |Protein Serine-Threonine Kinases/genetics/*metabolism [MESH]The Hippo signaling functions through the Notch signaling to regulate (epmc).pdf DeepDyve Pubget Overpricing