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10.1016/j.canlet.2017.01.034 http://scihub22266oqcxt.onion/10.1016/j.canlet.2017.01.034 C5901897!5901897!28153789     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cancer+Lett 2017 ; 392 (ä): 51-9 Nephropedia Template TP {{tp|p=28153789|t=2017. MEK5-ERK5 Signaling in Cancer: Implications for Targeted Therapy |pdf=|usr=}}{{28153789}} gab.com Text MEK5-ERK5 Signaling in Cancer: Implications for Targeted Therapy JO: Cancer Lett http://www.kidney.de/pget.php?&tw=1&pmid=28153789 #FOAvip Mitogen-activated protein kinases (MAPKs) regulate diverse cellular processes including proliferation, cell survival, differentiation, and apoptosis. While conventional MAPK constituents have well-defined roles in oncogenesis, the MAPK kinase 5-extracellular signal-regulated kinase 5 (MEK5-ERK5) pathway has only recently emerged in cancer research. In this review, we consider the MEK5 signaling cascade, focusing specifically on its involvement in drug resistance and regulation of aggressive cancer phenotypes. Moreover, we explore the role of MEK5 in tumorigenesis and metastatic progression, discussing the discrepancies in preclinical studies and assessing its viability as a therapeutic target for anti-cancer agents. Twit Text FOAVip MEK5-ERK5 Signaling in Cancer: Implications for Targeted Therapy ????Cancer Lett http://www.kidney.de/pget.php?&tw=1&pmid=28153789 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28153789 #FOAvip English Wikipedia <ref>{{Cite pmid|28153789}}</ref> MEK5-ERK5 Signaling in Cancer: Implications for Targeted Therapy #MMPMID28153789 Hoang VT; Yan TJ; Cavanaugh JE; Flaherty PT; Beckman BS; Burow ME Cancer Lett 2017[Apr]; 392 (ä): 51-9 PMID28153789show ga Mitogen-activated protein kinases (MAPKs) regulate diverse cellular processes including proliferation, cell survival, differentiation, and apoptosis. While conventional MAPK constituents have well-defined roles in oncogenesis, the MAPK kinase 5-extracellular signal-regulated kinase 5 (MEK5-ERK5) pathway has only recently emerged in cancer research. In this review, we consider the MEK5 signaling cascade, focusing specifically on its involvement in drug resistance and regulation of aggressive cancer phenotypes. Moreover, we explore the role of MEK5 in tumorigenesis and metastatic progression, discussing the discrepancies in preclinical studies and assessing its viability as a therapeutic target for anti-cancer agents. äMEK5-ERK5 Signaling in Cancer: Implications for Targeted Therapy (epmc).pdf DeepDyve Pubget Overpricing