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2018 ; 2018
(ä): 8256193
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Predictive Role of Serum Cytokine Profiles in Acute Kidney Injury after Living
Donor Liver Transplantation
#MMPMID29805315
Chae MS
; Kim Y
; Chung HS
; Park CS
; Lee J
; Choi JH
; Hong SH
Mediators Inflamm
2018[]; 2018
(ä): 8256193
PMID29805315
show ga
INTRODUCTION: Previous studies have shown that a higher serum interleukin- (IL-)
6 level is associated with a higher risk of acute kidney injury (AKI) development
after major nontransplant surgery. Our study investigated the potential
association of preoperative serum cytokine profiles with new AKI development in
patients who underwent living donor liver transplantation (LDLT). METHODS: Serum
levels of cytokines IL-2, IL-6, IL-10, IL-12, and IL-17, interferon-?, and tumor
necrosis factor- (TNF-) ? were measured in 226 LDLT recipients preoperatively and
analyzed retrospectively. Recipients with a preoperative functional impairment of
the kidney were excluded. AKI was defined according to Kidney Disease: Improving
Global Outcomes (KDIGO) criteria. RESULTS: In a univariate regression model,
IL-6, IL-17, and TNF-? levels showed an association with AKI development after
LDLT. Multivariate analysis showed an independent association of the preoperative
serum IL-6 level with AKI development after LDLT and a significant relationship
between higher serum IL-6 levels and a greater likelihood of developing AKI.
Serum IL-6 levels were higher in patients with stage 3 AKI than in patients who
did not develop AKI. CONCLUSIONS: Our results support the need for further
investigations of IL-6 as a predictor of AKI development in patients undergoing
LDLT.