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10.1038/ni.3683 http://scihub22266oqcxt.onion/10.1038/ni.3683 C5901650!5901650 !28166218     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28166218 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Immunol 2017 ; 18 (4 ): 412-421 Nephropedia Template TP {{tp|p=28166218 |t=2017. Critical role of IRF1 and BATF in forming chromatin landscape during type 1 regulatory cell differentiation |pdf=|usr=}}{{28166218 }} gab.com Text Critical role of IRF1 and BATF in forming chromatin landscape during type 1 regulatory cell differentiation JO: Nat Immunol http://www.kidney.de/pget.php?&tw=1&pmid=28166218 #FOAvip Type 1 regulatory T cells (Tr1 cells) are induced by interleukin-27 (IL-27) and have critical roles in the control of autoimmunity and resolution of inflammation. We found that the transcription factors IRF1 and BATF were induced early on after treatment with IL-27 and were required for the differentiation and function of Tr1 cells in vitro and in vivo. Epigenetic and transcriptional analyses revealed that both transcription factors influenced chromatin accessibility and expression of the genes required for Tr1 cell function. IRF1 and BATF deficiencies uniquely altered the chromatin landscape, suggesting that these factors serve a pioneering function during Tr1 cell differentiation. Twit Text FOAVip Critical role of IRF1 and BATF in forming chromatin landscape during type 1 regulatory cell differentiation ????Nat Immunol http://www.kidney.de/pget.php?&tw=1&pmid=28166218 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28166218 #FOAvip English Wikipedia <ref>{{Cite pmid|28166218 }}</ref> Critical role of IRF1 and BATF in forming chromatin landscape during type 1 regulatory cell differentiation #MMPMID28166218 Karwacz K ; Miraldi ER ; Pokrovskii M ; Madi A ; Yosef N ; Wortman I ; Chen X ; Watters A ; Carriero N ; Awasthi A ; Regev A ; Bonneau R ; Littman D ; Kuchroo VK Nat Immunol 2017[Apr]; 18 (4 ): 412-421 PMID28166218 show ga Type 1 regulatory T cells (Tr1 cells) are induced by interleukin-27 (IL-27) and have critical roles in the control of autoimmunity and resolution of inflammation. We found that the transcription factors IRF1 and BATF were induced early on after treatment with IL-27 and were required for the differentiation and function of Tr1 cells in vitro and in vivo. Epigenetic and transcriptional analyses revealed that both transcription factors influenced chromatin accessibility and expression of the genes required for Tr1 cell function. IRF1 and BATF deficiencies uniquely altered the chromatin landscape, suggesting that these factors serve a pioneering function during Tr1 cell differentiation. |Animals [MESH] |Autoimmune Diseases/genetics/immunology/metabolism [MESH] |Autoimmunity [MESH] |Basic-Leucine Zipper Transcription Factors/genetics/*metabolism [MESH] |Cell Differentiation/genetics/*immunology [MESH] |Chromatin/genetics/*metabolism [MESH] |Cluster Analysis [MESH] |Cytokines/metabolism/pharmacology [MESH] |Gene Expression Profiling [MESH] |Gene Expression Regulation [MESH] |Gene Regulatory Networks [MESH] |Interferon Regulatory Factor-1/genetics/*metabolism [MESH] |Mice [MESH] |Mice, Knockout [MESH] |Promoter Regions, Genetic [MESH] |T-Lymphocyte Subsets/drug effects/immunology/metabolism [MESH] |T-Lymphocytes, Regulatory/cytology/drug effects/*immunology/*metabolism [MESH] |Transcription Factors/metabolism [MESH]Critical role of IRF1 and BATF in forming chromatin landscape during t(epmc).pdf DeepDyve Pubget Overpricing