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10.1002/ana.25146 http://scihub22266oqcxt.onion/10.1002/ana.25146 C5901412!5901412!29328521     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29328521.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Ann+Neurol 2018 ; 83 (2): 283-94 Nephropedia Template TP {{tp|p=29328521|t=2018. Central vein sign differentiates Multiple Sclerosis from central nervous system inflammatory vasculopathies |pdf=|usr=}}{{29328521}} gab.com Text Central vein sign differentiates Multiple Sclerosis from central nervous system inflammatory vasculopathies JO: Ann Neurol http://www.kidney.de/pget.php?&tw=1&pmid=29328521 #FOAvip Objectives: In multiple sclerosis (MS), magnetic resonance imaging (MRI) is a sensitive tool for detecting white matter lesions, but its diagnostic specificity is still suboptimal; ambiguous cases are frequent in clinical practice. Detection of perivenular lesions in the brain (the ?central vein sign?) improves the pathological specificity of MS diagnosis, but comprehensive evaluation of this MRI biomarker in MS?mimicking inflammatory and/or autoimmune diseases, such as central nervous system (CNS) inflammatory vasculopathies, is lacking. In a multicenter study, we assessed the frequency of perivenular lesions in MS versus systemic autoimmune diseases with CNS involvement and primary angiitis of the CNS (PACNS). Methods: In 31 patients with inflammatory CNS vasculopathies and 52 with relapsing?remitting MS, 3?dimensional T2*?weighted and T2?fluid?attenuated inversion recovery images were obtained during a single MRI acquisition after gadolinium injection. For each lesion, the central vein sign was evaluated according to consensus guidelines. For each patient, lesion count, volume, and brain location, as well as fulfillment of dissemination in space MRI criteria, were assessed. Results: MS showed higher frequency of perivenular lesions (median?=?88%) than did inflammatory CNS vasculopathies (14%), without overlap between groups or differences between 3T and 1.5T MRI. Among inflammatory vasculopathies, Behçet disease showed the highest median frequency of perivenular lesions (34%), followed by PACNS (14%), antiphospholipid syndromes (12%), Sjögren syndrome (11%), and systemic lupus erythematosus (0%). When a threshold of 50% perivenular lesions was applied, central vein sign discriminated MS from inflammatory vasculopathies with a diagnostic accuracy of 100%. Interpretation: The central vein sign differentiates inflammatory CNS vasculopathies from MS at standard clinical magnetic field strengths. Ann Neurol 2018;83:283?294 Twit Text FOAVip Central vein sign differentiates Multiple Sclerosis from central nervous system inflammatory vasculopathies ????Ann Neurol http://www.kidney.de/pget.php?&tw=1&pmid=29328521 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29328521 #FOAvip English Wikipedia <ref>{{Cite pmid|29328521}}</ref> Central vein sign differentiates Multiple Sclerosis from central nervous system inflammatory vasculopathies #MMPMID29328521 Maggi P; Absinta M; Grammatico M; Vuolo L; Emmi G; Carlucci G; Spagni G; Barilaro A; Repice AM; Emmi L; Prisco D; Martinelli V; Scotti R; Sadeghi N; Perrotta G; Sati P; Dachy B; Reich DS; Filippi M; Massacesi L Ann Neurol 2018[Feb]; 83 (2): 283-94 PMID29328521show ga Objectives: In multiple sclerosis (MS), magnetic resonance imaging (MRI) is a sensitive tool for detecting white matter lesions, but its diagnostic specificity is still suboptimal; ambiguous cases are frequent in clinical practice. Detection of perivenular lesions in the brain (the ?central vein sign?) improves the pathological specificity of MS diagnosis, but comprehensive evaluation of this MRI biomarker in MS?mimicking inflammatory and/or autoimmune diseases, such as central nervous system (CNS) inflammatory vasculopathies, is lacking. In a multicenter study, we assessed the frequency of perivenular lesions in MS versus systemic autoimmune diseases with CNS involvement and primary angiitis of the CNS (PACNS). Methods: In 31 patients with inflammatory CNS vasculopathies and 52 with relapsing?remitting MS, 3?dimensional T2*?weighted and T2?fluid?attenuated inversion recovery images were obtained during a single MRI acquisition after gadolinium injection. For each lesion, the central vein sign was evaluated according to consensus guidelines. For each patient, lesion count, volume, and brain location, as well as fulfillment of dissemination in space MRI criteria, were assessed. Results: MS showed higher frequency of perivenular lesions (median?=?88%) than did inflammatory CNS vasculopathies (14%), without overlap between groups or differences between 3T and 1.5T MRI. Among inflammatory vasculopathies, Behçet disease showed the highest median frequency of perivenular lesions (34%), followed by PACNS (14%), antiphospholipid syndromes (12%), Sjögren syndrome (11%), and systemic lupus erythematosus (0%). When a threshold of 50% perivenular lesions was applied, central vein sign discriminated MS from inflammatory vasculopathies with a diagnostic accuracy of 100%. Interpretation: The central vein sign differentiates inflammatory CNS vasculopathies from MS at standard clinical magnetic field strengths. Ann Neurol 2018;83:283?294 äCentral vein sign differentiates Multiple Sclerosis from central nervo(epmc).pdf DeepDyve Pubget Overpricing