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10.1002/mc.22788 http://scihub22266oqcxt.onion/10.1002/mc.22788 C5900930!5900930 !29380446     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29380446 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Mol+Carcinog 2018 ; 57 (5 ): 640-652 Nephropedia Template TP {{tp|p=29380446 |t=2018. SH2B1 promotes epithelial-mesenchymal transition through the IRS1/?-catenin signaling axis in lung adenocarcinoma |pdf=|usr=}}{{29380446 }} gab.com Text SH2B1 promotes epithelial-mesenchymal transition through the IRS1/ -catenin signaling axis in lung adenocarcinoma JO: Mol Carcinog http://www.kidney.de/pget.php?&tw=1&pmid=29380446 #FOAvip Lung adenocarcinoma (LADC), the most prevalent type of human lung cancer, is characterized by many molecular abnormalities. SH2B1, a member of the SH2-domain containing family, have recently been shown to act as tumor activators in multiple cancers, including LADC. However, the mechanisms underlying SH2B1 overexpression are not completely understood. Here, we reported that SH2B1 expression levels were significantly upregulated and positively associated with EMT markers and poor patient survival in LADC specimens. Modulation of SH2B1 levels had distinct effects on cell proliferation, cell cycle, migration, invasion, and morphology in A549 and H1299 cells in vitro and in vivo. At the molecular level, overexpression of SH2B1 resulted in the upregulation of the EMT markers, especially induced ?-catenin accumulation and activated ?-catenin signaling to promote LADC cell proliferation and metastasis, while silencing SH2B1 had the opposite effect. Furthermore, ectopic expression of SH2B1 in H1299 cells increased IRS1 expression level. Reduced expression of IRS1 considerably inhibited H1299 cell proliferation, migration, and invasion which were driven by SH2B1 overexpression. Collectively, these results provide unequivocal evidence to establish that SH2B1-IRS1-?-catenin axis is required for promoting EMT, and might prove to be a promising strategy for restraining tumor progression in LADC patients. Twit Text FOAVip SH2B1 promotes epithelial-mesenchymal transition through the IRS1/ -catenin signaling axis in lung adenocarcinoma ????Mol Carcinog http://www.kidney.de/pget.php?&tw=1&pmid=29380446 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29380446 #FOAvip English Wikipedia <ref>{{Cite pmid|29380446 }}</ref> SH2B1 promotes epithelial-mesenchymal transition through the IRS1/?-catenin signaling axis in lung adenocarcinoma #MMPMID29380446 Wang S ; Cheng Y ; Gao Y ; He Z ; Zhou W ; Chang R ; Peng Z ; Zheng Y ; Duan C ; Zhang C Mol Carcinog 2018[May]; 57 (5 ): 640-652 PMID29380446 show ga Lung adenocarcinoma (LADC), the most prevalent type of human lung cancer, is characterized by many molecular abnormalities. SH2B1, a member of the SH2-domain containing family, have recently been shown to act as tumor activators in multiple cancers, including LADC. However, the mechanisms underlying SH2B1 overexpression are not completely understood. Here, we reported that SH2B1 expression levels were significantly upregulated and positively associated with EMT markers and poor patient survival in LADC specimens. Modulation of SH2B1 levels had distinct effects on cell proliferation, cell cycle, migration, invasion, and morphology in A549 and H1299 cells in vitro and in vivo. At the molecular level, overexpression of SH2B1 resulted in the upregulation of the EMT markers, especially induced ?-catenin accumulation and activated ?-catenin signaling to promote LADC cell proliferation and metastasis, while silencing SH2B1 had the opposite effect. Furthermore, ectopic expression of SH2B1 in H1299 cells increased IRS1 expression level. Reduced expression of IRS1 considerably inhibited H1299 cell proliferation, migration, and invasion which were driven by SH2B1 overexpression. Collectively, these results provide unequivocal evidence to establish that SH2B1-IRS1-?-catenin axis is required for promoting EMT, and might prove to be a promising strategy for restraining tumor progression in LADC patients. |*Up-Regulation [MESH] |A549 Cells [MESH] |Adaptor Proteins, Signal Transducing/*metabolism [MESH] |Adenocarcinoma of Lung/*metabolism [MESH] |Animals [MESH] |Cell Line, Tumor [MESH] |Cell Movement [MESH] |Cell Proliferation [MESH] |Disease Progression [MESH] |Epithelial-Mesenchymal Transition [MESH] |Female [MESH] |Gene Expression Regulation, Neoplastic [MESH] |Humans [MESH] |Insulin Receptor Substrate Proteins/*metabolism [MESH] |Male [MESH] |Mice [MESH] |Signal Transduction [MESH] |Survival Analysis [MESH] |Xenograft Model Antitumor Assays [MESH]SH2B1 promotes epithelial-mesenchymal transition through the IRS1/?-ca(epmc).pdf DeepDyve Pubget Overpricing