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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Endocrinol+Diabetes+Metab+Case+Rep
2018 ; 2018
(ä): ä Nephropedia Template TP
gab.com Text
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English Wikipedia
One too many diabetes: the combination of hyperglycaemic hyperosmolar state and
central diabetes insipidus
#MMPMID29675260
Burmazovic S
; Henzen C
; Brander L
; Cioccari L
Endocrinol Diabetes Metab Case Rep
2018[]; 2018
(ä): ä PMID29675260
show ga
The combination of hyperosmolar hyperglycaemic state and central diabetes
insipidus is unusual and poses unique diagnostic and therapeutic challenges for
clinicians. In a patient with diabetes mellitus presenting with polyuria and
polydipsia, poor glycaemic control is usually the first aetiology that is
considered, and achieving glycaemic control remains the first course of action.
However, severe hypernatraemia, hyperglycaemia and discordance between
urine-specific gravity and urine osmolality suggest concurrent symptomatic
diabetes insipidus. We report a rare case of concurrent manifestation of
hyperosmolar hyperglycaemic state and central diabetes insipidus in a patient
with a history of craniopharyngioma. LEARNING POINTS: In patients with diabetes
mellitus presenting with polyuria and polydipsia, poor glycaemic control is
usually the first aetiology to be considered.However, a history of
craniopharyngioma, severe hypernatraemia, hyperglycaemia and discordance between
urine-specific gravity and osmolality provide evidence of concurrent diabetes
insipidus.Therefore, if a patient with diabetes mellitus presents with severe
hypernatraemia, hyperglycaemia, a low or low normal urinary-specific gravity and
worsening polyuria despite correction of hyperglycaemia, concurrent diabetes
insipidus should be sought.