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10.1101/gad.312397.118

http://scihub22266oqcxt.onion/10.1101/gad.312397.118
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C5900709!5900709!29572261
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suck abstract from ncbi


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pmid29572261      Genes+Dev 2018 ; 32 (5-6): 347-58
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  • Clock-dependent chromatin topology modulates circadian transcription and behavior #MMPMID29572261
  • Mermet J; Yeung J; Hurni C; Mauvoisin D; Gustafson K; Jouffe C; Nicolas D; Emmenegger Y; Gobet C; Franken P; Gachon F; Naef F
  • Genes Dev 2018[Mar]; 32 (5-6): 347-58 PMID29572261show ga
  • Using circular chromosome conformation capture (4C-seq), Mermet et al. discovered oscillatory promoter?enhancer interactions along the 24-h cycle in mouse livers and kidneys. Deleting a contacted intronic enhancer element in the Cryptochrome 1 (Cry1) gene reduced the daily dynamics of Cry1 transcriptional burst frequency and shortened the circadian period of locomotor activity rhythms.
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