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10.3389/fimmu.2018.00613 http://scihub22266oqcxt.onion/10.3389/fimmu.2018.00613 C5900062!5900062!29686669     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Immunol 2018 ; 9 (ä): ä Nephropedia Template TP {{tp|p=29686669|t=2018. Nuclear Factor-kappaB in Autoimmunity: Man and Mouse |pdf=|usr=}}{{29686669}} gab.com Text Nuclear Factor-kappaB in Autoimmunity: Man and Mouse JO: Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=29686669 #FOAvip NF-?B (nuclear factor-kappa B) is a transcription complex crucial for host defense mediated by innate and adaptive immunity, where canonical NF-?B signaling, mediated by nuclear translocation of RelA, c-Rel, and p50, is important for immune cell activation, differentiation, and survival. Non-canonical signaling mediated by nuclear translocation of p52 and RelB contributes to lymphocyte maturation and survival and is also crucial for lymphoid organogenesis. We outline NF-?B signaling and regulation, then summarize important molecular contributions of NF-?B to mechanisms of self-tolerance. We relate these mechanisms to autoimmune phenotypes described in what is now a substantial catalog of immune defects conferred by mutations in NF-?B pathways in mouse models. Finally, we describe Mendelian autoimmune syndromes arising from human NF-?B mutations, and speculate on implications for understanding sporadic autoimmune disease. Twit Text FOAVip Nuclear Factor-kappaB in Autoimmunity: Man and Mouse ????Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=29686669 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29686669 #FOAvip English Wikipedia <ref>{{Cite pmid|29686669}}</ref> Nuclear Factor-kappaB in Autoimmunity: Man and Mouse #MMPMID29686669 Miraghazadeh B; Cook MC Front Immunol 2018[]; 9 (ä): ä PMID29686669show ga NF-?B (nuclear factor-kappa B) is a transcription complex crucial for host defense mediated by innate and adaptive immunity, where canonical NF-?B signaling, mediated by nuclear translocation of RelA, c-Rel, and p50, is important for immune cell activation, differentiation, and survival. Non-canonical signaling mediated by nuclear translocation of p52 and RelB contributes to lymphocyte maturation and survival and is also crucial for lymphoid organogenesis. We outline NF-?B signaling and regulation, then summarize important molecular contributions of NF-?B to mechanisms of self-tolerance. We relate these mechanisms to autoimmune phenotypes described in what is now a substantial catalog of immune defects conferred by mutations in NF-?B pathways in mouse models. Finally, we describe Mendelian autoimmune syndromes arising from human NF-?B mutations, and speculate on implications for understanding sporadic autoimmune disease. äNuclear Factor-kappaB in Autoimmunity: Man and Mouse (epmc).pdf DeepDyve Pubget Overpricing