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2018 ; 10
(2
): 327-337
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Light-induced chromophore and protein responses and mechanical signal
transduction of BLUF proteins
#MMPMID29235080
Fujisawa T
; Masuda S
Biophys Rev
2018[Apr]; 10
(2
): 327-337
PMID29235080
show ga
Photoreceptor proteins have been used to study how protein conformational changes
are induced by alterations in their environments and how their signals are
transmitted to downstream factors to dictate physiological responses. These
proteins are attractive models because their signal transduction aspects and
structural changes can be precisely regulated in vivo and in vitro based on light
intensity. Among the known photoreceptors, members of the blue light-using flavin
(BLUF) protein family have been well characterized with regard to how they
control various light-dependent physiological responses in several
microorganisms. Herein, we summarize our current understanding of their
photoactivation and signal-transduction mechanisms. For signal transduction, we
review recent studies concerning how the BLUF protein, PixD, transmits a
light-induced signal to its downstream factor, PixE, to modulate phototaxis of
the cyanobacterium Synechocystis sp. PCC6803.