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suck abstract from ncbi


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pmid29222808
      Biophys+Rev 2018 ; 10 (2 ): 219-227
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  • "Just a spoonful of sugar ": import of sialic acid across bacterial cell membranes #MMPMID29222808
  • North RA ; Horne CR ; Davies JS ; Remus DM ; Muscroft-Taylor AC ; Goyal P ; Wahlgren WY ; Ramaswamy S ; Friemann R ; Dobson RCJ
  • Biophys Rev 2018[Apr]; 10 (2 ): 219-227 PMID29222808 show ga
  • Eukaryotic cell surfaces are decorated with a complex array of glycoconjugates that are usually capped with sialic acids, a large family of over 50 structurally distinct nine-carbon amino sugars, the most common member of which is N-acetylneuraminic acid. Once made available through the action of neuraminidases, bacterial pathogens and commensals utilise host-derived sialic acid by degrading it for energy or repurposing the sialic acid onto their own cell surface to camouflage the bacterium from the immune system. A functional sialic acid transporter has been shown to be essential for the uptake of sialic acid in a range of human bacterial pathogens and important for host colonisation and persistence. Here, we review the state-of-play in the field with respect to the molecular mechanisms by which these bio-nanomachines transport sialic acids across bacterial cell membranes.
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