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10.1073/pnas.1720542115 http://scihub22266oqcxt.onion/10.1073/pnas.1720542115 C5899464!5899464!29588418     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2018 ; 115 (15): E3351-60 Nephropedia Template TP {{tp|p=29588418|t=2018. Successful reprogramming of cellular protein production through mRNA delivered by functionalized lipid nanoparticles |pdf=|usr=}}{{29588418}} gab.com Text Successful reprogramming of cellular protein production through mRNA delivered by functionalized lipid nanoparticles JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=29588418 #FOAvip mRNA treatments represent an exciting approach to cure diseases that cannot be tackled with current therapeutics. However, the delivery of mRNA to target cells remains a challenge, but among the existing alternatives, lipid nanoparticles (LNPs) offer a promising answer to this. Here we determine the structure of LNPs encapsulating mRNA, consisting of a lipid mixture already evaluated in clinical trials. We show that the lipids are not homogeneously distributed across the LNP, and one of the lipids is localized mainly at its surface. The structural information enabled us to design LNPs that successfully modify intracellular protein production in two clinically relevant cell types. Our findings and approach provide a framework for understanding and optimizing vehicles for mRNA delivery. Twit Text FOAVip Successful reprogramming of cellular protein production through mRNA delivered by functionalized lipid nanoparticles ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=29588418 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29588418 #FOAvip English Wikipedia <ref>{{Cite pmid|29588418}}</ref> Successful reprogramming of cellular protein production through mRNA delivered by functionalized lipid nanoparticles #MMPMID29588418 Yanez Arteta M; Kjellman T; Bartesaghi S; Wallin S; Wu X; Kvist AJ; Dabkowska A; Székely N; Radulescu A; Bergenholtz J; Lindfors L Proc Natl Acad Sci U S A 2018[Apr]; 115 (15): E3351-60 PMID29588418show ga mRNA treatments represent an exciting approach to cure diseases that cannot be tackled with current therapeutics. However, the delivery of mRNA to target cells remains a challenge, but among the existing alternatives, lipid nanoparticles (LNPs) offer a promising answer to this. Here we determine the structure of LNPs encapsulating mRNA, consisting of a lipid mixture already evaluated in clinical trials. We show that the lipids are not homogeneously distributed across the LNP, and one of the lipids is localized mainly at its surface. The structural information enabled us to design LNPs that successfully modify intracellular protein production in two clinically relevant cell types. Our findings and approach provide a framework for understanding and optimizing vehicles for mRNA delivery. äSuccessful reprogramming of cellular protein production through mRNA d(epmc).pdf DeepDyve Pubget Overpricing