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10.1073/pnas.1719138115 http://scihub22266oqcxt.onion/10.1073/pnas.1719138115 C5899451!5899451!29581298     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2018 ; 115 (15): E3481-90 Nephropedia Template TP {{tp|p=29581298|t=2018. RNA-mediated gene regulation is less evolvable than transcriptional regulation |pdf=|usr=}}{{29581298}} gab.com Text RNA-mediated gene regulation is less evolvable than transcriptional regulation JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=29581298 #FOAvip Cells regulate the activity of genes in a variety of ways. For example, they regulate transcription through DNA binding proteins called transcription factors, and they regulate mRNA stability and processing through RNA binding proteins. Based on current knowledge, transcriptional regulation is more widespread and is involved in many more evolutionary adaptations than posttranscriptional regulation. The reason could be that transcriptional regulation is studied more intensely. We suggest instead that transcriptional regulation harbors an intrinsic evolutionary advantage: when mutations change transcriptional regulation, they are more likely to bring forth novel patterns of such regulation. That is, transcriptional regulation is more evolvable. Our analysis suggests a reason why a specific kind of gene regulation is especially abundant in the living world. Twit Text FOAVip RNA-mediated gene regulation is less evolvable than transcriptional regulation ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=29581298 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29581298 #FOAvip English Wikipedia <ref>{{Cite pmid|29581298}}</ref> RNA-mediated gene regulation is less evolvable than transcriptional regulation #MMPMID29581298 Payne JL; Khalid F; Wagner A Proc Natl Acad Sci U S A 2018[Apr]; 115 (15): E3481-90 PMID29581298show ga Cells regulate the activity of genes in a variety of ways. For example, they regulate transcription through DNA binding proteins called transcription factors, and they regulate mRNA stability and processing through RNA binding proteins. Based on current knowledge, transcriptional regulation is more widespread and is involved in many more evolutionary adaptations than posttranscriptional regulation. The reason could be that transcriptional regulation is studied more intensely. We suggest instead that transcriptional regulation harbors an intrinsic evolutionary advantage: when mutations change transcriptional regulation, they are more likely to bring forth novel patterns of such regulation. That is, transcriptional regulation is more evolvable. Our analysis suggests a reason why a specific kind of gene regulation is especially abundant in the living world. äRNA-mediated gene regulation is less evolvable than transcriptional re(epmc).pdf DeepDyve Pubget Overpricing