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Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Stem+Cell+Res+Ther 2018 ; 9 (ä): ä Nephropedia Template TP
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Stem cell-derived mitochondria transplantation: a novel strategy and the challenges for the treatment of tissue injury #MMPMID29653590
Wang J; Li H; Yao Y; Zhao T; Chen Yy; Shen Yl; Wang Ll; Zhu Y
Stem Cell Res Ther 2018[]; 9 (ä): ä PMID29653590show ga
Damage of mitochondria in the initial period of tissue injury aggravates the severity of injury. Restoration of mitochondria dysfunction and mitochondrial-based therapeutics represent a potentially effective therapeutic strategy. Recently, mitochondrial transfer from stem cells has been demonstrated to play a significant role in rescuing injured tissues. The possible mechanisms of mitochondria released from stem cells, the pathways of mitochondria transfer between the donor stem cells and recipient cells, and the internalization of mitochondria into recipient cells are discussed. Moreover, a novel strategy for tissue injury based on the concept of stem cell-derived mitochondrial transplantation is pointed out, and the advantages and challenges are summarized.