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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Stem+Cell+Res+Ther
2018 ; 9
(1
): 106
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gab.com Text
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Stem cell-derived mitochondria transplantation: a novel strategy and the
challenges for the treatment of tissue injury
#MMPMID29653590
Wang J
; Li H
; Yao Y
; Zhao T
; Chen YY
; Shen YL
; Wang LL
; Zhu Y
Stem Cell Res Ther
2018[Apr]; 9
(1
): 106
PMID29653590
show ga
Damage of mitochondria in the initial period of tissue injury aggravates the
severity of injury. Restoration of mitochondria dysfunction and
mitochondrial-based therapeutics represent a potentially effective therapeutic
strategy. Recently, mitochondrial transfer from stem cells has been demonstrated
to play a significant role in rescuing injured tissues. The possible mechanisms
of mitochondria released from stem cells, the pathways of mitochondria transfer
between the donor stem cells and recipient cells, and the internalization of
mitochondria into recipient cells are discussed. Moreover, a novel strategy for
tissue injury based on the concept of stem cell-derived mitochondrial
transplantation is pointed out, and the advantages and challenges are summarized.