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2018 ; 51
(3
): ä Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Laboratory-confirmed respiratory infections as triggers for acute myocardial
infarction and stroke: a self-controlled case series analysis of national linked
datasets from Scotland
#MMPMID29563170
Warren-Gash C
; Blackburn R
; Whitaker H
; McMenamin J
; Hayward AC
Eur Respir J
2018[Mar]; 51
(3
): ä PMID29563170
show ga
While acute respiratory tract infections can trigger cardiovascular events, the
differential effect of specific organisms is unknown. This is important to guide
vaccine policy.Using national infection surveillance data linked to the Scottish
Morbidity Record, we identified adults with a first myocardial infarction or
stroke from January 1, 2004 to December 31, 2014 and a record of
laboratory-confirmed respiratory infection during this period. Using
self-controlled case series analysis, we generated age- and season-adjusted
incidence ratios (IRs) for myocardial infarction (n=1227) or stroke (n=762) after
infections compared with baseline time.We found substantially increased
myocardial infarction rates in the week after Streptococcus pneumoniae and
influenza virus infection: adjusted IRs for days 1-3 were 5.98 (95% CI 2.47-14.4)
and 9.80 (95% CI 2.37-40.5), respectively. Rates of stroke after infection were
similarly high and remained elevated to 28?days: day 1-3 adjusted IRs 12.3 (95%
CI 5.48-27.7) and 7.82 (95% CI 1.07-56.9) for S. pneumoniae and influenza virus,
respectively. Although other respiratory viruses were associated with raised
point estimates for both outcomes, only the day 4-7 estimate for stroke reached
statistical significance.We showed a marked cardiovascular triggering effect of
S. pneumoniae and influenza virus, which highlights the need for adequate
pneumococcal and influenza vaccine uptake. Further research is needed into
vascular effects of noninfluenza respiratory viruses.