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10.1371/journal.pone.0195594 http://scihub22266oqcxt.onion/10.1371/journal.pone.0195594 C5898761!5898761 !29652902     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29652902 &cmd=llinks): Failed to open stream: HTTP request failed! 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Relations between right ventricular morphology and clinical, electrical and genetic parameters in Brugada Syndrome |pdf=|usr=}}{{29652902 }} gab.com Text Relations between right ventricular morphology and clinical, electrical and genetic parameters in Brugada Syndrome JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=29652902 #FOAvip BACKGROUND: Increasing evidence suggests the presence of structural changes affecting the right ventricular outflow tract (RVOT) in patients with Brugada Syndrome (BrS). The aim of this study was to characterise the RV morphology in BrS and explore associations between morphologic, clinical, electrical, and genetic parameters using non-invasive multimodality testing. METHODS: Consecutive BrS patients (recruited 2013-2015) underwent clinical assessment, dedicated RV imaging using cardiac magnetic resonance (CMR) imaging (unless contra-indicated), electrical assessment (electrocardiogram, Holter monitoring, signal-averaged ECG[SAECG]) and genotyping. Morphologic data were compared to matched control and unmatched ARVC (arrhythmogenic right ventricular cardiomyopathy) cohorts, and potential associations between morphologic parameters and other variables were explored. RESULTS: BrS patients (n = 42, male 86%, age 46±12 years) exhibited normal global RV volume and function, comparable to control, in contrast to significantly larger, impaired RVs in ARVC cohort (RVESV p = 0.0001; RVEDV p<0.0001, RVEF p = 0.002). Compared with control, BrS patients exhibited larger RVOT volumes (7.4 ± 0.7 vs 5.8 ± 0.7 mL/m2, p<0.0001) and wall motion abnormalities (RWMA) (31% vs 0%, p = 0.005); compared with ARVC cohort, the RVOT volumes were similar (7.4 ± 0.7 vs, 8.1 ± 1.7, p = 0.52) and there were less RWMA (31% vs 76%, p = 0.01). Overall 67% BrS patients had abnormal RVOT morphology. Patients with abnormal RVOT tended to be older (48 ± 12 y vs 41 ± 12y, p = 0.06). Rare genetic variants were only observed in patients with abnormal RVOT morphology (36% vs 0%, p = 0.02). CONCLUSIONS: Patients with BrS frequently exhibit structural abnormalities localised to the RVOT and these changes may be age- and gene-dependent. Twit Text FOAVip Relations between right ventricular morphology and clinical, electrical and genetic parameters in Brugada Syndrome ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=29652902 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29652902 #FOAvip English Wikipedia <ref>{{Cite pmid|29652902 }}</ref> Relations between right ventricular morphology and clinical, electrical and genetic parameters in Brugada Syndrome #MMPMID29652902 Gray B ; Gnanappa GK ; Bagnall RD ; Femia G ; Yeates L ; Ingles J ; Burns C ; Puranik R ; Grieve SM ; Semsarian C ; Sy RW PLoS One 2018[]; 13 (4 ): e0195594 PMID29652902 show ga BACKGROUND: Increasing evidence suggests the presence of structural changes affecting the right ventricular outflow tract (RVOT) in patients with Brugada Syndrome (BrS). The aim of this study was to characterise the RV morphology in BrS and explore associations between morphologic, clinical, electrical, and genetic parameters using non-invasive multimodality testing. METHODS: Consecutive BrS patients (recruited 2013-2015) underwent clinical assessment, dedicated RV imaging using cardiac magnetic resonance (CMR) imaging (unless contra-indicated), electrical assessment (electrocardiogram, Holter monitoring, signal-averaged ECG[SAECG]) and genotyping. Morphologic data were compared to matched control and unmatched ARVC (arrhythmogenic right ventricular cardiomyopathy) cohorts, and potential associations between morphologic parameters and other variables were explored. RESULTS: BrS patients (n = 42, male 86%, age 46±12 years) exhibited normal global RV volume and function, comparable to control, in contrast to significantly larger, impaired RVs in ARVC cohort (RVESV p = 0.0001; RVEDV p<0.0001, RVEF p = 0.002). Compared with control, BrS patients exhibited larger RVOT volumes (7.4 ± 0.7 vs 5.8 ± 0.7 mL/m2, p<0.0001) and wall motion abnormalities (RWMA) (31% vs 0%, p = 0.005); compared with ARVC cohort, the RVOT volumes were similar (7.4 ± 0.7 vs, 8.1 ± 1.7, p = 0.52) and there were less RWMA (31% vs 76%, p = 0.01). Overall 67% BrS patients had abnormal RVOT morphology. Patients with abnormal RVOT tended to be older (48 ± 12 y vs 41 ± 12y, p = 0.06). Rare genetic variants were only observed in patients with abnormal RVOT morphology (36% vs 0%, p = 0.02). CONCLUSIONS: Patients with BrS frequently exhibit structural abnormalities localised to the RVOT and these changes may be age- and gene-dependent. |*Electrophysiological Phenomena [MESH] |Brugada Syndrome/diagnostic imaging/*pathology/*physiopathology [MESH] |Electrocardiography [MESH] |Female [MESH] |Heart Ventricles/*pathology/*physiopathology [MESH] |Humans [MESH] |Magnetic Resonance Imaging [MESH] |Male [MESH]Relations between right ventricular morphology and clinical, electrica(epmc).pdf DeepDyve Pubget Overpricing