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10.1186/s12943-018-0832-y http://scihub22266oqcxt.onion/10.1186/s12943-018-0832-y C5897927!5897927!29650000     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Mol+Cancer 2018 ; 17 (ä): ä Nephropedia Template TP {{tp|p=29650000|t=2018. Favorable outcome of patients with lung adenocarcinoma harboring POLE mutations and expressing high PD-L1 |pdf=|usr=}}{{29650000}} gab.com Text Favorable outcome of patients with lung adenocarcinoma harboring POLE mutations and expressing high PD-L1 JO: Mol Cancer http://www.kidney.de/pget.php?&tw=1&pmid=29650000 #FOAvip Mutations in polymerase ? (POLE) confer favorable prognosis and outcomes in various cancer types, but their role in non-small cell lung cancer (NSCLC) is unknown. Utilizing the data of 513 patients with adenocarcinoma (LUAD) and 497 patients with squamous cell carcinoma (LUSC) from The Cancer Genome Atlas (TCGA) cohort, we tested the prognostic value of POLE mutations and programmed cell death ligand 1 (PD-L1) expression in the two main subtypes of NSCLC. POLE mutation is a favorable biomarker for the improved overall survival (OS) of the LUSC patients (P?= 0.033, 28 mutant vs. 469 wildtype patients), but not that of the LUAD patients (P?= 0.12, 31 mutant vs. 482 wildtype patients). POLE-mutant LUAD patients with high expression of PD-L1 (Mut-High, n =?6) exhibited improved OS (P?= 0.024) when compared to POLE-mutant patients with low PD-L1 expression (Mut-Low, n =?24) and other patients without POLE mutation (n =?476). This benefit was not due to the high content of the tumor infiltrating lymphocytes. Instead, the antitumor immune response was activated in Mut-High patients so that these patients were likely responding more effectively to immuno-oncology (IO) treatments; whereas genes involved with metabolic pathways were enriched in Mut-Low group, which may cause the decreased OS of these patients. Our study sheds light on the molecular basis of NSCLC and adds to our understanding of responses to chemotherapy and IO therapy.Electronic supplementary material: The online version of this article (10.1186/s12943-018-0832-y) contains supplementary material, which is available to authorized users. Twit Text FOAVip Favorable outcome of patients with lung adenocarcinoma harboring POLE mutations and expressing high PD-L1 ????Mol Cancer http://www.kidney.de/pget.php?&tw=1&pmid=29650000 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29650000 #FOAvip English Wikipedia <ref>{{Cite pmid|29650000}}</ref> Favorable outcome of patients with lung adenocarcinoma harboring POLE mutations and expressing high PD-L1 #MMPMID29650000 Liu L; Ruiz J; O?Neill SS; Grant SC; Petty WJ; Yang M; Chen K; Topaloglu U; Pasche B; Zhang W Mol Cancer 2018[]; 17 (ä): ä PMID29650000show ga Mutations in polymerase ? (POLE) confer favorable prognosis and outcomes in various cancer types, but their role in non-small cell lung cancer (NSCLC) is unknown. Utilizing the data of 513 patients with adenocarcinoma (LUAD) and 497 patients with squamous cell carcinoma (LUSC) from The Cancer Genome Atlas (TCGA) cohort, we tested the prognostic value of POLE mutations and programmed cell death ligand 1 (PD-L1) expression in the two main subtypes of NSCLC. POLE mutation is a favorable biomarker for the improved overall survival (OS) of the LUSC patients (P?= 0.033, 28 mutant vs. 469 wildtype patients), but not that of the LUAD patients (P?= 0.12, 31 mutant vs. 482 wildtype patients). POLE-mutant LUAD patients with high expression of PD-L1 (Mut-High, n =?6) exhibited improved OS (P?= 0.024) when compared to POLE-mutant patients with low PD-L1 expression (Mut-Low, n =?24) and other patients without POLE mutation (n =?476). This benefit was not due to the high content of the tumor infiltrating lymphocytes. Instead, the antitumor immune response was activated in Mut-High patients so that these patients were likely responding more effectively to immuno-oncology (IO) treatments; whereas genes involved with metabolic pathways were enriched in Mut-Low group, which may cause the decreased OS of these patients. Our study sheds light on the molecular basis of NSCLC and adds to our understanding of responses to chemotherapy and IO therapy.Electronic supplementary material: The online version of this article (10.1186/s12943-018-0832-y) contains supplementary material, which is available to authorized users. äFavorable outcome of patients with lung adenocarcinoma harboring POLE (epmc).pdf DeepDyve Pubget Overpricing