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10.1242/jcs.208223 http://scihub22266oqcxt.onion/10.1242/jcs.208223 C5897718!5897718 !29361531     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29361531 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Cell+Sci 2018 ; 131 (5 ): ä Nephropedia Template TP {{tp|p=29361531 |t=2018. Epithelial and stromal circadian clocks are inversely regulated by their mechano-matrix environment |pdf=|usr=}}{{29361531 }} gab.com Text Epithelial and stromal circadian clocks are inversely regulated by their mechano-matrix environment JO: J Cell Sci http://www.kidney.de/pget.php?&tw=1&pmid=29361531 #FOAvip The circadian clock is an autonomous molecular feedback loop inside almost every cell in the body. We have shown that the mammary epithelial circadian clock is regulated by the cellular microenvironment. Moreover, a stiff extracellular matrix dampens the oscillations of the epithelial molecular clock. Here, we extend this analysis to other tissues and cell types, and identify an inverse relationship between circadian clocks in epithelia and fibroblasts. Epithelial cells from mammary gland, lung and skin have significantly stronger oscillations of clock genes in soft 3D microenvironments, compared to stiff 2D environments. Fibroblasts isolated from the same tissues show the opposite response, exhibiting stronger oscillations and more prolonged rhythmicity in stiff microenvironments. RNA analysis identified that a subset of mammary epithelial clock genes, and their regulators, are upregulated in 3D microenvironments in soft compared to stiff gels. Furthermore, the same genes are inversely regulated in fibroblasts isolated from the same tissues. Thus, our data reveal for the first time an intrinsic difference in the regulation of circadian genes in epithelia and fibroblasts. Twit Text FOAVip Epithelial and stromal circadian clocks are inversely regulated by their mechano-matrix environment ????J Cell Sci http://www.kidney.de/pget.php?&tw=1&pmid=29361531 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29361531 #FOAvip English Wikipedia <ref>{{Cite pmid|29361531 }}</ref> Epithelial and stromal circadian clocks are inversely regulated by their mechano-matrix environment #MMPMID29361531 Williams J ; Yang N ; Wood A ; Zindy E ; Meng QJ ; Streuli CH J Cell Sci 2018[Mar]; 131 (5 ): ä PMID29361531 show ga The circadian clock is an autonomous molecular feedback loop inside almost every cell in the body. We have shown that the mammary epithelial circadian clock is regulated by the cellular microenvironment. Moreover, a stiff extracellular matrix dampens the oscillations of the epithelial molecular clock. Here, we extend this analysis to other tissues and cell types, and identify an inverse relationship between circadian clocks in epithelia and fibroblasts. Epithelial cells from mammary gland, lung and skin have significantly stronger oscillations of clock genes in soft 3D microenvironments, compared to stiff 2D environments. Fibroblasts isolated from the same tissues show the opposite response, exhibiting stronger oscillations and more prolonged rhythmicity in stiff microenvironments. RNA analysis identified that a subset of mammary epithelial clock genes, and their regulators, are upregulated in 3D microenvironments in soft compared to stiff gels. Furthermore, the same genes are inversely regulated in fibroblasts isolated from the same tissues. Thus, our data reveal for the first time an intrinsic difference in the regulation of circadian genes in epithelia and fibroblasts. |Animals [MESH] |Cellular Microenvironment/*genetics [MESH] |Circadian Clocks/*genetics [MESH] |Epithelial Cells/metabolism [MESH] |Female [MESH] |Fibroblasts/metabolism [MESH] |Lung/growth & development/metabolism [MESH] |Mammary Glands, Animal/growth & development/metabolism [MESH] |Mechanotransduction, Cellular/*genetics [MESH] |Mice [MESH] |Period Circadian Proteins/*genetics [MESH] |RNA/genetics [MESH] |Skin/growth & development/metabolism [MESH]Epithelial and stromal circadian clocks are inversely regulated by the(epmc).pdf DeepDyve Pubget Overpricing