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10.3389/fmed.2018.00085 http://scihub22266oqcxt.onion/10.3389/fmed.2018.00085 C5897590!5897590!29682505     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Med+(Lausanne) 2018 ; 5 (ä): ä Nephropedia Template TP {{tp|p=29682505|t=2018. Overview on Clinical Relevance of Intra-Tumor Heterogeneity |pdf=|usr=}}{{29682505}} gab.com Text Overview on Clinical Relevance of Intra-Tumor Heterogeneity JO: Front Med (Lausanne) http://www.kidney.de/pget.php?&tw=1&pmid=29682505 #FOAvip Today, clinical evaluation of tumor heterogeneity is an emergent issue to improve clinical oncology. In particular, intra-tumor heterogeneity (ITH) is closely related to cancer progression, resistance to therapy, and recurrences. It is interconnected with complex molecular mechanisms including spatial and temporal phenomena, which are often peculiar for every single patient. This review tries to describe all the types of ITH including morphohistological ITH, and at the molecular level clonal ITH derived from genomic instability and nonclonal ITH derived from microenvironment interaction. It is important to consider the different types of ITH as a whole for any patient to investigate on cancer progression, prognosis, and treatment opportunities. From a practical point of view, analytical methods that are widely accessible today, or will be in the near future, are evaluated to investigate the complex pattern of ITH in a reproducible way for a clinical application. Twit Text FOAVip Overview on Clinical Relevance of Intra-Tumor Heterogeneity ????Front Med (Lausanne) http://www.kidney.de/pget.php?&tw=1&pmid=29682505 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29682505 #FOAvip English Wikipedia <ref>{{Cite pmid|29682505}}</ref> Overview on Clinical Relevance of Intra-Tumor Heterogeneity #MMPMID29682505 Stanta G; Bonin S Front Med (Lausanne) 2018[]; 5 (ä): ä PMID29682505show ga Today, clinical evaluation of tumor heterogeneity is an emergent issue to improve clinical oncology. In particular, intra-tumor heterogeneity (ITH) is closely related to cancer progression, resistance to therapy, and recurrences. It is interconnected with complex molecular mechanisms including spatial and temporal phenomena, which are often peculiar for every single patient. This review tries to describe all the types of ITH including morphohistological ITH, and at the molecular level clonal ITH derived from genomic instability and nonclonal ITH derived from microenvironment interaction. It is important to consider the different types of ITH as a whole for any patient to investigate on cancer progression, prognosis, and treatment opportunities. From a practical point of view, analytical methods that are widely accessible today, or will be in the near future, are evaluated to investigate the complex pattern of ITH in a reproducible way for a clinical application. äOverview on Clinical Relevance of Intra-Tumor Heterogeneity (epmc).pdf DeepDyve Pubget Overpricing