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10.1038/s41467-018-03636-8 http://scihub22266oqcxt.onion/10.1038/s41467-018-03636-8 C5897525!5897525!29650949     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2018 ; 9 (ä): ä Nephropedia Template TP {{tp|p=29650949|t=2018. Treating cat allergy with monoclonal IgG antibodies that bind allergen and prevent IgE engagement |pdf=|usr=}}{{29650949}} gab.com Text Treating cat allergy with monoclonal IgG antibodies that bind allergen and prevent IgE engagement JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=29650949 #FOAvip Acute allergic symptoms are caused by allergen-induced crosslinking of allergen-specific immunoglobulin E (IgE) bound to Fc-epsilon receptors on effector cells. Desensitization with allergen-specific immunotherapy (SIT) has been used for over a century, but the dominant protective mechanism remains unclear. One consistent observation is increased allergen-specific IgG, thought to competitively block allergen binding to IgE. Here we show that the blocking potency of the IgG response to Cat-SIT is heterogeneous. Next, using two potent, pre-selected allergen-blocking monoclonal IgG antibodies against the immunodominant cat allergen Fel d 1, we demonstrate that increasing the IgG/IgE ratio reduces the allergic response in mice and in cat-allergic patients: a single dose of blocking IgG reduces clinical symptoms in response to nasal provocation (ANCOVA, p?=?0.0003), with a magnitude observed at day 8 similar to that reported with years of conventional SIT. This study suggests that simply augmenting the blocking IgG/IgE ratio may reverse allergy. Twit Text FOAVip Treating cat allergy with monoclonal IgG antibodies that bind allergen and prevent IgE engagement ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=29650949 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29650949 #FOAvip English Wikipedia <ref>{{Cite pmid|29650949}}</ref> Treating cat allergy with monoclonal IgG antibodies that bind allergen and prevent IgE engagement #MMPMID29650949 Orengo JM; Radin AR; Kamat V; Badithe A; Ben LH; Bennett BL; Zhong S; Birchard D; Limnander A; Rafique A; Bautista J; Kostic A; Newell D; Duan X; Franklin MC; Olson W; Huang T; Gandhi NA; Lipsich L; Stahl N; Papadopoulos NJ; Murphy AJ; Yancopoulos GD Nat Commun 2018[]; 9 (ä): ä PMID29650949show ga Acute allergic symptoms are caused by allergen-induced crosslinking of allergen-specific immunoglobulin E (IgE) bound to Fc-epsilon receptors on effector cells. Desensitization with allergen-specific immunotherapy (SIT) has been used for over a century, but the dominant protective mechanism remains unclear. One consistent observation is increased allergen-specific IgG, thought to competitively block allergen binding to IgE. Here we show that the blocking potency of the IgG response to Cat-SIT is heterogeneous. Next, using two potent, pre-selected allergen-blocking monoclonal IgG antibodies against the immunodominant cat allergen Fel d 1, we demonstrate that increasing the IgG/IgE ratio reduces the allergic response in mice and in cat-allergic patients: a single dose of blocking IgG reduces clinical symptoms in response to nasal provocation (ANCOVA, p?=?0.0003), with a magnitude observed at day 8 similar to that reported with years of conventional SIT. This study suggests that simply augmenting the blocking IgG/IgE ratio may reverse allergy. äTreating cat allergy with monoclonal IgG antibodies that bind allergen(epmc).pdf DeepDyve Pubget Overpricing