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10.1038/s41598-018-21807-x http://scihub22266oqcxt.onion/10.1038/s41598-018-21807-x C5897522!5897522!29650971     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2018 ; 8 (ä): ä Nephropedia Template TP {{tp|p=29650971|t=2018. Hydrogen sulfide inhibits epithelial-mesenchymal transition in peritoneal mesothelial cells |pdf=|usr=}}{{29650971}} gab.com Text Hydrogen sulfide inhibits epithelial-mesenchymal transition in peritoneal mesothelial cells JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=29650971 #FOAvip Peritoneal fibrosis (PS) determines the long-term outcome of peritoneal dialysis (PD). We previous confirmed that hydrogen sulfide (H2S) inhibited PS, but its cellular mechanism was not fully elucidated. Epithelial-mesenchymal transition (EMT) of mesothelial cells (MCs) is an important cellular event of PS, we therefore investigated whether EMT can be affected by H2S in MCs. Rats were treated with 4.25% -glucose PD fluids plus lipopolysaccharide for 28 days to produce PS, and NaHS (56??g/kg.d) was given simultaneously. NaHS (56??g/kg.d) reduced the deposition of collagen in the submesothelial zone compared with the PS group. In primarily cultured rat MCs, 4.25% -glucose PD fluid induced EMT in MCs featured as loss of ZO-1 and Cytokeratin, and increase of ?-SMA, plasminogen activator inhibitor 1, fibronectin and TGF-?1 proteins. PD fluid also increased IL-6 and monocyte chemotactic protein-1 mRNA expressions as well as the phosphorylation of Smad2/3 and Smad3. NaHS (50?300??mol/L) reversed the above alterations with the optimal dose at 100??mol/L. Thus, exogenous H2S improves PS by inhibiting EMT in MCs. The anti-EMT effect of H2S is associated with the inhibition of inflammation and TGF-?1-Smad signal pathway. Twit Text FOAVip Hydrogen sulfide inhibits epithelial-mesenchymal transition in peritoneal mesothelial cells ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=29650971 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29650971 #FOAvip English Wikipedia <ref>{{Cite pmid|29650971}}</ref> Hydrogen sulfide inhibits epithelial-mesenchymal transition in peritoneal mesothelial cells #MMPMID29650971 Cheng S; Lu Y; Li Y; Gao L; Shen H; Song K Sci Rep 2018[]; 8 (ä): ä PMID29650971show ga Peritoneal fibrosis (PS) determines the long-term outcome of peritoneal dialysis (PD). We previous confirmed that hydrogen sulfide (H2S) inhibited PS, but its cellular mechanism was not fully elucidated. Epithelial-mesenchymal transition (EMT) of mesothelial cells (MCs) is an important cellular event of PS, we therefore investigated whether EMT can be affected by H2S in MCs. Rats were treated with 4.25% -glucose PD fluids plus lipopolysaccharide for 28 days to produce PS, and NaHS (56??g/kg.d) was given simultaneously. NaHS (56??g/kg.d) reduced the deposition of collagen in the submesothelial zone compared with the PS group. In primarily cultured rat MCs, 4.25% -glucose PD fluid induced EMT in MCs featured as loss of ZO-1 and Cytokeratin, and increase of ?-SMA, plasminogen activator inhibitor 1, fibronectin and TGF-?1 proteins. PD fluid also increased IL-6 and monocyte chemotactic protein-1 mRNA expressions as well as the phosphorylation of Smad2/3 and Smad3. NaHS (50?300??mol/L) reversed the above alterations with the optimal dose at 100??mol/L. Thus, exogenous H2S improves PS by inhibiting EMT in MCs. The anti-EMT effect of H2S is associated with the inhibition of inflammation and TGF-?1-Smad signal pathway. äHydrogen sulfide inhibits epithelial-mesenchymal transition in periton(epmc).pdf DeepDyve Pubget Overpricing