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10.1038/s41467-018-03716-9 http://scihub22266oqcxt.onion/10.1038/s41467-018-03716-9 C5897412!5897412 !29650964     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29650964 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Commun 2018 ; 9 (1 ): 1423 Nephropedia Template TP {{tp|p=29650964 |t=2018. TSPAN15 interacts with BTRC to promote oesophageal squamous cell carcinoma metastasis via activating NF-?B signaling |pdf=|usr=}}{{29650964 }} gab.com Text TSPAN15 interacts with BTRC to promote oesophageal squamous cell carcinoma metastasis via activating NF- B signaling JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=29650964 #FOAvip Beta-transducin repeat containing E3 ubiquitin protein ligase (BTRC) is crucial for the degradation of I?B?. Our previous transcriptome sequencing analysis revealed that tetraspanin 15 (TSPAN15) was significantly upregulated in clinical oesophageal squamous cell carcinoma (OSCC) tissues. Here, we show that high TSPAN15 expression in OSCC tissues is significantly associated with lymph node and distant metastasis, advanced clinical stage, and poor prognosis. Elevated TSPAN15 expression is, in part, caused by the reduction of miR-339-5p. Functional studies demonstrate that TSPAN15 promotes metastatic capabilities of OSCC cells. We further show that TSPAN15 specifically interacts with BTRC to promote the ubiquitination and proteasomal degradation of p-I?B?, and thereby triggers NF-?B nuclear translocation and subsequent activation of transcription of several metastasis-related genes, including ICAM1, VCAM1, uPA, MMP9, TNF?, and CCL2. Collectively, our findings indicate that TSPAN15 may serve as a new biomarker and/or provide a novel therapeutic target to OSCC patients. Twit Text FOAVip TSPAN15 interacts with BTRC to promote oesophageal squamous cell carcinoma metastasis via activating NF- B signaling ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=29650964 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29650964 #FOAvip English Wikipedia <ref>{{Cite pmid|29650964 }}</ref> TSPAN15 interacts with BTRC to promote oesophageal squamous cell carcinoma metastasis via activating NF-?B signaling #MMPMID29650964 Zhang B ; Zhang Z ; Li L ; Qin YR ; Liu H ; Jiang C ; Zeng TT ; Li MQ ; Xie D ; Li Y ; Guan XY ; Zhu YH Nat Commun 2018[Apr]; 9 (1 ): 1423 PMID29650964 show ga Beta-transducin repeat containing E3 ubiquitin protein ligase (BTRC) is crucial for the degradation of I?B?. Our previous transcriptome sequencing analysis revealed that tetraspanin 15 (TSPAN15) was significantly upregulated in clinical oesophageal squamous cell carcinoma (OSCC) tissues. Here, we show that high TSPAN15 expression in OSCC tissues is significantly associated with lymph node and distant metastasis, advanced clinical stage, and poor prognosis. Elevated TSPAN15 expression is, in part, caused by the reduction of miR-339-5p. Functional studies demonstrate that TSPAN15 promotes metastatic capabilities of OSCC cells. We further show that TSPAN15 specifically interacts with BTRC to promote the ubiquitination and proteasomal degradation of p-I?B?, and thereby triggers NF-?B nuclear translocation and subsequent activation of transcription of several metastasis-related genes, including ICAM1, VCAM1, uPA, MMP9, TNF?, and CCL2. Collectively, our findings indicate that TSPAN15 may serve as a new biomarker and/or provide a novel therapeutic target to OSCC patients. |*Gene Expression Regulation, Neoplastic [MESH] |Aged [MESH] |Animals [MESH] |Carcinoma, Squamous Cell/*genetics/metabolism/pathology [MESH] |Cell Line, Tumor [MESH] |Chemokine CCL2/genetics/metabolism [MESH] |Esophageal Neoplasms/*genetics/metabolism/pathology [MESH] |Esophageal Squamous Cell Carcinoma [MESH] |Female [MESH] |Humans [MESH] |Intercellular Adhesion Molecule-1/genetics/metabolism [MESH] |Lymphatic Metastasis [MESH] |Male [MESH] |Matrix Metalloproteinase 9/genetics/metabolism [MESH] |Mice [MESH] |Mice, Nude [MESH] |MicroRNAs/genetics/metabolism [MESH] |Middle Aged [MESH] |NF-KappaB Inhibitor alpha/genetics/metabolism [MESH] |NF-kappa B/*genetics/metabolism [MESH] |Neoplasm Grading [MESH] |Neoplasm Staging [MESH] |Neoplasm Transplantation [MESH] |RNA, Small Interfering/genetics/metabolism [MESH] |Signal Transduction [MESH] |Tetraspanins/antagonists & inhibitors/*genetics/metabolism [MESH] |Tumor Necrosis Factor-alpha/genetics/metabolism [MESH] |Urokinase-Type Plasminogen Activator/genetics/metabolism [MESH] |Vascular Cell Adhesion Molecule-1/genetics/metabolism [MESH]TSPAN15 interacts with BTRC to promote oesophageal squamous cell carci(epmc).pdf DeepDyve Pubget Overpricing