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10.1038/s41467-018-03704-z http://scihub22266oqcxt.onion/10.1038/s41467-018-03704-z C5897363!5897363!29650963     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2018 ; 9 (ä): ä Nephropedia Template TP {{tp|p=29650963|t=2018. Epigenetic control of IL-23 expression in keratinocytes is important for chronic skin inflammation |pdf=|usr=}}{{29650963}} gab.com Text Epigenetic control of IL-23 expression in keratinocytes is important for chronic skin inflammation JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=29650963 #FOAvip The chronic skin inflammation psoriasis is crucially dependent on the IL-23/IL-17 cytokine axis. Although IL-23 is expressed by psoriatic keratinocytes and immune cells, only the immune cell-derived IL-23 is believed to be disease relevant. Here we use a genetic mouse model to show that keratinocyte-produced IL-23 is sufficient to cause a chronic skin inflammation with an IL-17 profile. Furthermore, we reveal a cell-autonomous nuclear function for the actin polymerizing molecule N-WASP, which controls IL-23 expression in keratinocytes by regulating the degradation of the histone methyltransferases G9a and GLP, and H3K9 dimethylation of the IL-23 promoter. This mechanism mediates the induction of IL-23 by TNF, a known inducer of IL-23 in psoriasis. Finally, in keratinocytes of psoriatic lesions a decrease in H3K9 dimethylation correlates with increased IL-23 expression, suggesting relevance for disease. Taken together, our data describe a molecular pathway where epigenetic regulation of keratinocytes can contribute to chronic skin inflammation. Twit Text FOAVip Epigenetic control of IL-23 expression in keratinocytes is important for chronic skin inflammation ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=29650963 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29650963 #FOAvip English Wikipedia <ref>{{Cite pmid|29650963}}</ref> Epigenetic control of IL-23 expression in keratinocytes is important for chronic skin inflammation #MMPMID29650963 Li H; Yao Q; Mariscal AG; Wu X; Hülse J; Pedersen E; Helin K; Waisman A; Vinkel C; Thomsen SF; Avgustinova A; Benitah SA; Lovato P; Norsgaard H; Mortensen MS; Veng L; Rozell B; Brakebusch C Nat Commun 2018[]; 9 (ä): ä PMID29650963show ga The chronic skin inflammation psoriasis is crucially dependent on the IL-23/IL-17 cytokine axis. Although IL-23 is expressed by psoriatic keratinocytes and immune cells, only the immune cell-derived IL-23 is believed to be disease relevant. Here we use a genetic mouse model to show that keratinocyte-produced IL-23 is sufficient to cause a chronic skin inflammation with an IL-17 profile. Furthermore, we reveal a cell-autonomous nuclear function for the actin polymerizing molecule N-WASP, which controls IL-23 expression in keratinocytes by regulating the degradation of the histone methyltransferases G9a and GLP, and H3K9 dimethylation of the IL-23 promoter. This mechanism mediates the induction of IL-23 by TNF, a known inducer of IL-23 in psoriasis. Finally, in keratinocytes of psoriatic lesions a decrease in H3K9 dimethylation correlates with increased IL-23 expression, suggesting relevance for disease. Taken together, our data describe a molecular pathway where epigenetic regulation of keratinocytes can contribute to chronic skin inflammation. äEpigenetic control of IL-23 expression in keratinocytes is important f(epmc).pdf DeepDyve Pubget Overpricing