Epidemiology and management of healthcare-associated bloodstream infections in
non-neutropenic immunosuppressed patients: a review of the literature
#MMPMID29662673
Calik Basaran N
; Ascioglu S
Ther Adv Infect Dis
2017[Nov]; 4
(6
): 171-191
PMID29662673
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Advancements in medicine have led to a considerable increase in the proportion of
patients living with severe chronic diseases, malignancies, and HIV infections.
Most of these conditions are associated with acquired immune-deficient states and
treatment-related immunosuppression. Although infections as a result of
neutropenia have long been recognized and strategies for management were
developed, non-neutropenic immunosuppression has been overlooked. Recently,
community-acquired infections in patients with frequent, significant exposure to
healthcare settings and procedures have been classified as 'healthcare-associated
infections' since they are more similar to hospital-acquired infections. Most of
the non-neutropenic immunosuppressed patients have frequent contact with the
healthcare system due to their chronic and severe diseases. In this review, we
focus on the healthcare-associated bloodstream infections in the most common
non-neutropenic immunosuppressive states and provide an update of the recent
evidence for the management of these infections.
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