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10.1126/sciimmunol.aai8153 http://scihub22266oqcxt.onion/10.1126/sciimmunol.aai8153 C5896567!5896567!28783670     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Immunol 2017 ; 2 (7): ä Nephropedia Template TP {{tp|p=28783670|t=2017. Low CD21 expression defines a population of recent germinal center graduates primed for plasma cell differentiation |pdf=|usr=}}{{28783670}} gab.com Text Low CD21 expression defines a population of recent germinal center graduates primed for plasma cell differentiation JO: Sci Immunol http://www.kidney.de/pget.php?&tw=1&pmid=28783670 #FOAvip In this study, we report that antigen-specific CD19+CD27+CD21lo (CD21lo) B cells are transiently induced 14-28 days after immunization, at the time germinal centers (GCs) peak. Although clonally related to memory B cells and plasmablasts, CD21lo cells form distinct clades within phylogenetic trees based on accumulated variable gene mutations, supporting exit from active GCs. CD21lo cells express a transcriptional program suggesting they are primed for plasma cell differentiation and are refractory to GC differentiation, although they do not spontaneously secrete antibody. Additionally, CD21lo cells differentially express multiple cell surface markers and have elevated intracellular levels of Blimp-1 and T-bet protein compared to memory B cells. Together, these data support a model in which CD21lo cells are recent GC graduates that represent a distinct population from CD27+ classical memory cells, are refractory to GC reentry and are predisposed to differentiate into long-lived plasma cells. Twit Text FOAVip Low CD21 expression defines a population of recent germinal center graduates primed for plasma cell differentiation ????Sci Immunol http://www.kidney.de/pget.php?&tw=1&pmid=28783670 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28783670 #FOAvip English Wikipedia <ref>{{Cite pmid|28783670}}</ref> Low CD21 expression defines a population of recent germinal center graduates primed for plasma cell differentiation #MMPMID28783670 Lau D; Lan LYL; Andrews SF; Henry C; Rojas KT; Neu KE; Huang M; Huang Y; DeKosky B; Palm AKE; Ippolito GC; Georgiou G; Wilson PC Sci Immunol 2017[Jan]; 2 (7): ä PMID28783670show ga In this study, we report that antigen-specific CD19+CD27+CD21lo (CD21lo) B cells are transiently induced 14-28 days after immunization, at the time germinal centers (GCs) peak. Although clonally related to memory B cells and plasmablasts, CD21lo cells form distinct clades within phylogenetic trees based on accumulated variable gene mutations, supporting exit from active GCs. CD21lo cells express a transcriptional program suggesting they are primed for plasma cell differentiation and are refractory to GC differentiation, although they do not spontaneously secrete antibody. Additionally, CD21lo cells differentially express multiple cell surface markers and have elevated intracellular levels of Blimp-1 and T-bet protein compared to memory B cells. Together, these data support a model in which CD21lo cells are recent GC graduates that represent a distinct population from CD27+ classical memory cells, are refractory to GC reentry and are predisposed to differentiate into long-lived plasma cells. äLow CD21 expression defines a population of recent germinal center gra(epmc).pdf DeepDyve Pubget Overpricing