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2018 ; 2018
(ä): 4520294
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Effective Immunotherapy in Bone Marrow Metastatic Melanoma Presenting with
Disseminated Intravascular Coagulopathy
#MMPMID29796327
Gbadamosi B
; Ezekwudo D
; Nayak B
; Yu Z
; Gjorgova-Gjeorgjievski S
; Xie M
; Robert C
; Jaiyesimi I
; Huben M
Case Reports Immunol
2018[]; 2018
(ä): 4520294
PMID29796327
show ga
Malignant melanoma is responsible for the majority of skin cancer deaths and is
increasing in prevalence. Bone marrow (BM) involvement by melanoma is rare in the
absence of widespread visceral disease. Here, we report the case of a 30-year-old
female who presented to the hospital with back pain, low-grade fever, and easy
bruising. She was found to be bicytopenic and in disseminated intravascular
coagulopathy (DIC). Surprisingly, BM biopsy showed extensive involvement by
metastatic malignant melanoma in the absence of visceral or brain metastasis. The
unique presentation of this case and the challenge of management of a potentially
treatable cancer in a critically ill patient are discussed, alongside a review of
published cases of metastatic melanoma in the BM and an exploration of currently
available treatment options. The excellent response of our patient to combined
immune checkpoint inhibitors has yet to be paralleled in the available
literature.