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Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Biomed+Res+Int 2018 ; 2018 (ä): ä Nephropedia Template TP
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Clinical and Experimental Evidences of Hydrogen Sulfide Involvement in Lead-Induced Hypertension #MMPMID29789795
Possomato-Vieira JS; Gonçalves-Rizzi VH; do Nascimento RA; Wandekin RR; Caldeira-Dias M; Chimini JS; da Silva MLS; Dias-Junior CA
Biomed Res Int 2018[]; 2018 (ä): ä PMID29789795show ga
Lead- (Pb-) induced hypertension has been shown in humans and experimental animals and cardiovascular effects of hydrogen sulfide (H2S) have been reported previously. However, no studies examined involvement of H2S in Pb-induced hypertension. We found increases in diastolic blood pressure and mean blood pressure in Pb-intoxicated humans followed by diminished H2S plasmatic levels. In order to expand our findings, male Wistar rats were divided into four groups: Saline, Pb, NaHS, and Pb + NaHS. Pb-intoxicated animals received intraperitoneally (i.p.) 1st dose of 8??g/100?g of Pb acetate and subsequent doses of 0.1??g/100?g for seven days and sodium hydrosulfide- (NaHS-) treated animals received i.p. NaHS injections (50??mol/kg/twice daily) for seven days. NaHS treatment blunted increases in systolic blood pressure, increased H2S plasmatic levels, and diminished whole-blood lead levels. Treatment with NaHS in Pb-induced hypertension seems to induce a protective role in rat aorta which is dependent on endothelium and seems to promote non-NO-mediated relaxation. Pb-intoxication increased oxidative stress in rats, while treatment with NaHS blunted increases in plasmatic MDA levels and increased antioxidant status of plasma. Therefore, H2S pathway may be involved in Pb-induced hypertension and treatment with NaHS exerts antihypertensive effect, promotes non-NO-mediated relaxation, and decreases oxidative stress in rats with Pb-induced hypertension.