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10.1126/scitranslmed.aah5505 http://scihub22266oqcxt.onion/10.1126/scitranslmed.aah5505 C5896001!5896001!28724577     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Transl+Med 2017 ; 9 (399): ä Nephropedia Template TP {{tp|p=28724577|t=2017. In situ expansion of engineered human liver tissue in a mouse model of chronic liver disease |pdf=|usr=}}{{28724577}} gab.com Text In situ expansion of engineered human liver tissue in a mouse model of chronic liver disease JO: Sci Transl Med http://www.kidney.de/pget.php?&tw=1&pmid=28724577 #FOAvip In spite of the vast collective experience in tissue engineering, control of both tissue architecture and scale are fundamental translational roadblocks. An experimental framework that enables investigation into how architecture and scaling may be coupled is needed. Here, we introduce an approach called ?SEEDs? (?in Situ Expansion of Engineered Devices?), in which we fabricate a structurally organized engineered tissue unit that expands in response to regenerative cues after implantation. We find that tissues containing pre-patterned human primary hepatocytes, endothelial cells, and stromal cells in degradable hydrogel expand over 50-fold over the course of 11 weeks in animals with liver injury, with concomitant increased function as characterized by the production of multiple human liver proteins. Histologically, we observe the emergence of stereotypical microstructure via coordinated growth of hepatocytes in close juxtaposition with a perfused, chimeric vasculature. Importantly, we demonstrate the utility of this platform for probing the impact of multicellular geometric architecture on tissue expansion in response to regenerative cues. This approach represents a hybrid strategy that harnesses both biology and engineering to deploy a limited cell mass more efficiently than either approach could do in isolation, and thus offers a new convergent paradigm for tissue engineering. Twit Text FOAVip In situ expansion of engineered human liver tissue in a mouse model of chronic liver disease ????Sci Transl Med http://www.kidney.de/pget.php?&tw=1&pmid=28724577 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28724577 #FOAvip English Wikipedia <ref>{{Cite pmid|28724577}}</ref> In situ expansion of engineered human liver tissue in a mouse model of chronic liver disease #MMPMID28724577 Stevens KR; Scull MA; Ramanan V; Fortin CL; Chaturvedi RR; Knouse KA; Xiao JW; Fung C; Mirabella T; Chen AX; McCue MG; Yang M; Fleming HE; Chung K; de Jong YP; Chen CS; Rice CM; Bhatia SN Sci Transl Med 2017[Jul]; 9 (399): ä PMID28724577show ga In spite of the vast collective experience in tissue engineering, control of both tissue architecture and scale are fundamental translational roadblocks. An experimental framework that enables investigation into how architecture and scaling may be coupled is needed. Here, we introduce an approach called ?SEEDs? (?in Situ Expansion of Engineered Devices?), in which we fabricate a structurally organized engineered tissue unit that expands in response to regenerative cues after implantation. We find that tissues containing pre-patterned human primary hepatocytes, endothelial cells, and stromal cells in degradable hydrogel expand over 50-fold over the course of 11 weeks in animals with liver injury, with concomitant increased function as characterized by the production of multiple human liver proteins. Histologically, we observe the emergence of stereotypical microstructure via coordinated growth of hepatocytes in close juxtaposition with a perfused, chimeric vasculature. Importantly, we demonstrate the utility of this platform for probing the impact of multicellular geometric architecture on tissue expansion in response to regenerative cues. This approach represents a hybrid strategy that harnesses both biology and engineering to deploy a limited cell mass more efficiently than either approach could do in isolation, and thus offers a new convergent paradigm for tissue engineering. äIn situ expansion of engineered human liver tissue in a mouse model of(epmc).pdf DeepDyve Pubget Overpricing