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10.1038/s41598-018-24198-1 http://scihub22266oqcxt.onion/10.1038/s41598-018-24198-1 C5895784!5895784 !29643425     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29643425 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Sci+Rep 2018 ; 8 (1 ): 5793 Nephropedia Template TP {{tp|p=29643425 |t=2018. A novel two-score system for interferon status segregates autoimmune diseases and correlates with clinical features |pdf=|usr=}}{{29643425 }} gab.com Text A novel two-score system for interferon status segregates autoimmune diseases and correlates with clinical features JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=29643425 #FOAvip Measurement of type I interferon (IFN-I) has potential to diagnose and stratify autoimmune diseases, but existing results have been inconsistent. Interferon-stimulated-gene (ISG) based methods may be affected by the modularity of the ISG transcriptome, cell-specific expression, response to IFN-subtypes and bimodality of expression. We developed and clinically validated a 2-score system (IFN-Score-A and -B) using Factor Analysis of 31 ISGs measured by TaqMan selected from 3-IFN-annotated modules. We evaluated these scores using in-vitro IFN stimulation as well as in sorted cells then clinically validated in a cohort of 328 autoimmune disease patients and healthy controls. ISGs varied in response to IFN-subtypes and both scores varied between cell subsets. IFN-Score-A differentiated Systemic Lupus Erythematosus (SLE) from both Rheumatoid Arthritis (RA) and Healthy Controls (HC) (both p?<?0.001), while IFN-Score-B differentiated SLE and RA from HC (both p?<?0.001). In SLE, both scores were associated with cutaneous and hematological (all p?<?0.05) but not musculoskeletal disease activity. Comparing with bimodal (IFN-high/low) classification, significant differences in IFN-scores were found between diagnostic groups within the IFN-high group. Our continuous 2-score system is more clinically relevant than a simple bimodal classification of IFN status. This system should allow improvement in diagnosis, stratification, and therapy in IFN-mediated autoimmunity. Twit Text FOAVip A novel two-score system for interferon status segregates autoimmune diseases and correlates with clinical features ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=29643425 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29643425 #FOAvip English Wikipedia <ref>{{Cite pmid|29643425 }}</ref> A novel two-score system for interferon status segregates autoimmune diseases and correlates with clinical features #MMPMID29643425 El-Sherbiny YM ; Psarras A ; Md Yusof MY ; Hensor EMA ; Tooze R ; Doody G ; Mohamed AAA ; McGonagle D ; Wittmann M ; Emery P ; Vital EM Sci Rep 2018[Apr]; 8 (1 ): 5793 PMID29643425 show ga Measurement of type I interferon (IFN-I) has potential to diagnose and stratify autoimmune diseases, but existing results have been inconsistent. Interferon-stimulated-gene (ISG) based methods may be affected by the modularity of the ISG transcriptome, cell-specific expression, response to IFN-subtypes and bimodality of expression. We developed and clinically validated a 2-score system (IFN-Score-A and -B) using Factor Analysis of 31 ISGs measured by TaqMan selected from 3-IFN-annotated modules. We evaluated these scores using in-vitro IFN stimulation as well as in sorted cells then clinically validated in a cohort of 328 autoimmune disease patients and healthy controls. ISGs varied in response to IFN-subtypes and both scores varied between cell subsets. IFN-Score-A differentiated Systemic Lupus Erythematosus (SLE) from both Rheumatoid Arthritis (RA) and Healthy Controls (HC) (both p? |Arthritis, Rheumatoid/*diagnosis/pathology [MESH] |Gene Expression Profiling/*methods [MESH] |Gene Expression Regulation/*drug effects [MESH] |Humans [MESH] |Immunologic Factors/*biosynthesis/genetics [MESH] |Interferons/*metabolism [MESH] |Lupus Erythematosus, Systemic/*diagnosis/pathology [MESH]A novel two-score system for interferon status segregates autoimmune d(epmc).pdf DeepDyve Pubget Overpricing