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10.1038/s41598-018-24256-8 http://scihub22266oqcxt.onion/10.1038/s41598-018-24256-8 C5895739!5895739 !29643415     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29643415 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Rep 2018 ; 8 (1 ): 5858 Nephropedia Template TP {{tp|p=29643415 |t=2018. Proteomic profiling of human cancer pseudopodia for the identification of anti-metastatic drug candidates |pdf=|usr=}}{{29643415 }} gab.com Text Proteomic profiling of human cancer pseudopodia for the identification of anti-metastatic drug candidates JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=29643415 #FOAvip Cancer metastasis causes approximately 90% of all cancer-related death and independent of the advancement of cancer therapy, a majority of late stage patients suffers from metastatic cancer. Metastasis implies cancer cell migration and invasion throughout the body. Migration requires the formation of pseudopodia in the direction of movement, but a detailed understanding of this process and accordingly strategies of prevention remain elusive. Here, we use quantitative proteomic profiling of human cancer pseudopodia to examine this mechanisms essential to metastasis formation, and identify potential candidates for pharmacological interference with the process. We demonstrate that Prohibitins (PHBs) are significantly enriched in the pseudopodia fraction derived from cancer cells, and knockdown of PHBs, as well as their chemical inhibition through Rocaglamide (Roc-A), efficiently reduces cancer cell migration. Twit Text FOAVip Proteomic profiling of human cancer pseudopodia for the identification of anti-metastatic drug candidates ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=29643415 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29643415 #FOAvip English Wikipedia <ref>{{Cite pmid|29643415 }}</ref> Proteomic profiling of human cancer pseudopodia for the identification of anti-metastatic drug candidates #MMPMID29643415 Choi S ; Bhagwat AM ; Al Mismar R ; Goswami N ; Ben Hamidane H ; Sun L ; Graumann J Sci Rep 2018[Apr]; 8 (1 ): 5858 PMID29643415 show ga Cancer metastasis causes approximately 90% of all cancer-related death and independent of the advancement of cancer therapy, a majority of late stage patients suffers from metastatic cancer. Metastasis implies cancer cell migration and invasion throughout the body. Migration requires the formation of pseudopodia in the direction of movement, but a detailed understanding of this process and accordingly strategies of prevention remain elusive. Here, we use quantitative proteomic profiling of human cancer pseudopodia to examine this mechanisms essential to metastasis formation, and identify potential candidates for pharmacological interference with the process. We demonstrate that Prohibitins (PHBs) are significantly enriched in the pseudopodia fraction derived from cancer cells, and knockdown of PHBs, as well as their chemical inhibition through Rocaglamide (Roc-A), efficiently reduces cancer cell migration. |Antineoplastic Agents/pharmacology/*therapeutic use [MESH] |Benzofurans/pharmacology [MESH] |Cell Line, Tumor [MESH] |Cell Movement/drug effects [MESH] |Gene Knockdown Techniques [MESH] |Humans [MESH] |Neoplasm Metastasis/*prevention & control [MESH] |Prohibitins [MESH] |Proteomics/methods [MESH] |Pseudopodia/drug effects/*metabolism [MESH]Proteomic profiling of human cancer pseudopodia for the identification(epmc).pdf DeepDyve Pubget Overpricing