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10.1038/s41598-018-24194-5 http://scihub22266oqcxt.onion/10.1038/s41598-018-24194-5 C5895618!5895618!29643359     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29643359&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2018 ; 8 (ä): ä Nephropedia Template TP {{tp|p=29643359|t=2018. IL23 and TGF-ß diminish macrophage associated metastasis in pancreatic carcinoma |pdf=|usr=}}{{29643359}} gab.com Text IL23 and TGF-ß diminish macrophage associated metastasis in pancreatic carcinoma JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=29643359 #FOAvip The precise role of tumor associated macrophages remains unclear in pancreatic ductal adenocarcinoma (PDAC) while TGF-ß has an unclear role in metastases formation. In order to understand the role of IL23, an interleukin associated with macrophage polarization, we investigated IL23 in the context of TGF-ß expression in PDAC. We hypothesized that IL23 expression is associated with metastatic development and survival in PDAC. We investigated IL23 and TGF-ß protein expression on resected PDAC patient tumor sections who were divided into short-term (<12 months) survivors and long-term (>30 months) survivors. Panc-1 cells treated with IL23, TGF-ß, macrophages, or combinations thereof, were orthotopically implanted into NSG mice. Patients in the long-term survivor group had higher IL23 protein expression (P?=?0.01). IL23 expression was linearly correlated with TGF-ß expression in patients in the short-term survivor group (P?=?0.038). Macrophages induce a higher rate of PDAC metastasis in the mouse model (P?=?0.02), which is abrogated by IL23 and TGF-ß treatment (P?<?0.001). Macrophages serve a critical role in PDAC tumor growth and metastasis. TGF-ß contributes to a less tumorigenic TME through regulation of macrophages. Macrophages increases PDAC primary tumor growth and metastases formation while combined IL23 and TGF-ß pre-treatment diminishes these processes. Twit Text FOAVip IL23 and TGF-ß diminish macrophage associated metastasis in pancreatic carcinoma ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=29643359 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29643359 #FOAvip English Wikipedia <ref>{{Cite pmid|29643359}}</ref> IL23 and TGF-ß diminish macrophage associated metastasis in pancreatic carcinoma #MMPMID29643359 Hussain SM; Reed LF; Krasnick BA; Miranda-Carboni G; Fields RC; Bi Y; Elahi A; Ajidahun A; Dickson PV; Deneve JL; Hawkins WG; Shibata D; Glazer ES Sci Rep 2018[]; 8 (ä): ä PMID29643359show ga The precise role of tumor associated macrophages remains unclear in pancreatic ductal adenocarcinoma (PDAC) while TGF-ß has an unclear role in metastases formation. In order to understand the role of IL23, an interleukin associated with macrophage polarization, we investigated IL23 in the context of TGF-ß expression in PDAC. We hypothesized that IL23 expression is associated with metastatic development and survival in PDAC. We investigated IL23 and TGF-ß protein expression on resected PDAC patient tumor sections who were divided into short-term (<12 months) survivors and long-term (>30 months) survivors. Panc-1 cells treated with IL23, TGF-ß, macrophages, or combinations thereof, were orthotopically implanted into NSG mice. Patients in the long-term survivor group had higher IL23 protein expression (P?=?0.01). IL23 expression was linearly correlated with TGF-ß expression in patients in the short-term survivor group (P?=?0.038). Macrophages induce a higher rate of PDAC metastasis in the mouse model (P?=?0.02), which is abrogated by IL23 and TGF-ß treatment (P? äIL23 and TGF-ß diminish macrophage associated metastasis in pancreatic(epmc).pdf DeepDyve Pubget Overpricing