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10.1097/MD.0000000000010192

http://scihub22266oqcxt.onion/10.1097/MD.0000000000010192
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C5895359!5895359!29561440
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suck abstract from ncbi


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pmid29561440      Medicine+(Baltimore) 2018 ; 97 (12): ä
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  • Lower hemoglobin transfusion trigger is associated with higher mortality in patients hospitalized with pneumonia #MMPMID29561440
  • Rahimi-Levene N; Koren-Michowitz M; Zeidenstein R; Peer V; Golik A; Ziv-Baran T
  • Medicine (Baltimore) 2018[Mar]; 97 (12): ä PMID29561440show ga
  • Patients hospitalized with pneumonia may require packed red blood cell (RBC) transfusion during their hospital stay. Patient survival may be associated with the transfusion trigger. These patients may need a higher hemoglobin (Hb) trigger than that suggested by the AABB guidelines (7?g/dL).The objective of this study was to evaluate the association between the initial transfusion Hb trigger and in-hospital mortality.A historical cohort study of all patients hospitalized in an internal medicine ward between 2009 and 2014 with pneumonia, who received at least 1 unit of RBC, was evaluated. The primary outcome was all-cause in-hospital mortality.One hundred males and 77 females with a median age of 80 (interquartile range 71?87) years were included. The median Hb trigger was 8.10?g/dL. Mortality rate was 56% in patients with Hb trigger ?7?g/dL, 43.8% in Hb trigger 7 to 8?g/dL, and 29.5% in Hb trigger >8?g/dL (P?=?.045). Patients in the 3 Hb trigger categories did not differ in age, sex, comorbidities, albumin, creatinine, C-reactive protein, white blood cells, and platelet counts. The result of a multivariate analysis showed that only lower Hb trigger (odds ratio [OR]? 7vs.>8?=?5.24, OR7?8vs.>8?=?2.13, P?=?.035) and higher neutrophil count (P?=?.012) were associated with increased in-hospital mortality.In conclusion, a lower transfusion trigger is associated with increased risk for in-hospital mortality in patients hospitalized with pneumonia requiring RBC transfusion.
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