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10.1038/pr.2017.237 http://scihub22266oqcxt.onion/10.1038/pr.2017.237 C5895100!5895100 !28945702     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28945702 &cmd=llinks): Failed to open stream: HTTP request failed! 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Mesenchymal stem cells in the pathogenesis and treatment of bronchopulmonary dysplasia: a clinical review |pdf=|usr=}}{{28945702 }} gab.com Text Mesenchymal stem cells in the pathogenesis and treatment of bronchopulmonary dysplasia: a clinical review JO: Pediatr Res http://www.kidney.de/pget.php?&tw=1&pmid=28945702 #FOAvip Advances in neonatal medicine have led to increased survival of infants born at the limits of viability, resulting in an increased incidence of bronchopulmonary dysplasia (BPD). BPD is a chronic lung disease of premature infants characterized by the arrest of alveolarization, fibroblast activation, and inflammation. BPD leads to significant morbidity and mortality in the neonatal period and is one of the leading causes of chronic lung disease in children. The past decade has brought a surge of trials investigating cellular therapies for the treatment of pulmonary diseases. Mesenchymal stem cells (MSCs) are of particular interest because of their ease of isolation, low immunogenicity, and anti-inflammatory and reparative properties. Clinical trials of MSCs have demonstrated short-term safety and tolerability; however, studies have also shown populations of MSCs with adverse pro-inflammatory and myofibroblastic characteristics. Cell-based therapies may represent the next breakthrough therapy for the treatment of BPD, however, there remain barriers to implementation as well as gaps in knowledge of the role of endogenous MSCs in the pathogenesis of BPD. Concurrent high-quality basic science, translational, and clinical studies investigating the fundamental pathophysiology underlying BPD, therapeutic mechanisms of exogenous MSCs, and logistics of translating cellular therapies will be important areas of future research. Twit Text FOAVip Mesenchymal stem cells in the pathogenesis and treatment of bronchopulmonary dysplasia: a clinical review ????Pediatr Res http://www.kidney.de/pget.php?&tw=1&pmid=28945702 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28945702 #FOAvip English Wikipedia <ref>{{Cite pmid|28945702 }}</ref> Mesenchymal stem cells in the pathogenesis and treatment of bronchopulmonary dysplasia: a clinical review #MMPMID28945702 Simones AA ; Beisang DJ ; Panoskaltsis-Mortari A ; Roberts KD Pediatr Res 2018[Jan]; 83 (1-2 ): 308-317 PMID28945702 show ga Advances in neonatal medicine have led to increased survival of infants born at the limits of viability, resulting in an increased incidence of bronchopulmonary dysplasia (BPD). BPD is a chronic lung disease of premature infants characterized by the arrest of alveolarization, fibroblast activation, and inflammation. BPD leads to significant morbidity and mortality in the neonatal period and is one of the leading causes of chronic lung disease in children. The past decade has brought a surge of trials investigating cellular therapies for the treatment of pulmonary diseases. Mesenchymal stem cells (MSCs) are of particular interest because of their ease of isolation, low immunogenicity, and anti-inflammatory and reparative properties. Clinical trials of MSCs have demonstrated short-term safety and tolerability; however, studies have also shown populations of MSCs with adverse pro-inflammatory and myofibroblastic characteristics. Cell-based therapies may represent the next breakthrough therapy for the treatment of BPD, however, there remain barriers to implementation as well as gaps in knowledge of the role of endogenous MSCs in the pathogenesis of BPD. Concurrent high-quality basic science, translational, and clinical studies investigating the fundamental pathophysiology underlying BPD, therapeutic mechanisms of exogenous MSCs, and logistics of translating cellular therapies will be important areas of future research. |*Mesenchymal Stem Cell Transplantation/adverse effects [MESH] |Animals [MESH] |Bronchopulmonary Dysplasia/physiopathology/*therapy [MESH] |Clinical Trials as Topic [MESH] |Fibroblasts/cytology [MESH] |Humans [MESH] |Infant [MESH] |Infant, Newborn [MESH] |Infant, Premature [MESH] |Inflammation [MESH] |Lung Diseases/therapy [MESH] |Mesenchymal Stem Cells/*cytology [MESH] |Patient Safety [MESH] |Phenotype [MESH]Mesenchymal stem cells in the pathogenesis and treatment of bronchopul(epmc).pdf DeepDyve Pubget Overpricing