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10.1097/AOG.0000000000001631

http://scihub22266oqcxt.onion/10.1097/AOG.0000000000001631
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suck abstract from ncbi


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pmid27607878
      Obstet+Gynecol 2016 ; 128 (4 ): 704-712
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  • Distinguishing Arterial Ischemic Stroke From Hypoxic-Ischemic Encephalopathy in the Neonate at Birth #MMPMID27607878
  • Adami RR ; Grundy ME ; Poretti A ; Felling RJ ; Lemmon M ; Graham EM
  • Obstet Gynecol 2016[Oct]; 128 (4 ): 704-712 PMID27607878 show ga
  • OBJECTIVE: To identify perinatal risk factors that can distinguish arterial ischemic stroke from hypoxic-ischemic encephalopathy at birth. METHODS: This is a cohort study of all neonates born at 35 weeks of gestation or greater admitted to our neonatal intensive care unit from January 1, 2010, to December 31, 2015, that compares neonates with stroke with those with hypoxic-ischemic encephalopathy undergoing whole-body hypothermia with abnormal brain magnetic resonance imaging. RESULTS: During this 6-year period, there were 22 neonates with stroke and 47 with hypoxic-ischemic encephalopathy undergoing whole-body hypothermia with abnormal magnetic resonance imaging. Three neonates triaged to hypothermia initially thought to have hypoxic-ischemic encephalopathy were later diagnosed with stroke. All neonates with stroke had a negative thrombophilia workup. Neonates with stroke had a significantly higher incidence of seizures and increased initial platelet counts on univariate analysis. A multivariable model of variables with P<.1 on univariate analysis present within 6 hours of birth found significant increases in nonreassuring fetal heart rate tracings, sentinel events, low Apgar score at 5 minutes, and metabolic acidosis at birth with hypoxic-ischemic encephalopathy. Stroke was associated with a significantly increased initial platelet count. CONCLUSION: Stroke is associated with increased initial platelet counts and is not associated with cesarean delivery for nonreassuring fetal heart rate tracings, sentinel events, or perinatal metabolic acidosis. Stroke is a form of neonatal brain injury not associated with perinatal risk factors that allow early identification.
  • |Acidosis/blood [MESH]
  • |Adult [MESH]
  • |Apgar Score [MESH]
  • |Brain Ischemia/complications [MESH]
  • |Diagnosis, Differential [MESH]
  • |Female [MESH]
  • |Fetal Distress/physiopathology [MESH]
  • |Heart Rate, Fetal [MESH]
  • |Humans [MESH]
  • |Hypoxia-Ischemia, Brain/blood/*diagnosis/*epidemiology [MESH]
  • |Incidence [MESH]
  • |Infant, Newborn [MESH]
  • |Magnetic Resonance Imaging [MESH]
  • |Male [MESH]
  • |Neuroimaging [MESH]
  • |Obstetric Labor Complications/epidemiology [MESH]
  • |Platelet Count [MESH]
  • |Pregnancy [MESH]
  • |Retrospective Studies [MESH]
  • |Risk Factors [MESH]
  • |Seizures/etiology [MESH]
  • |Stroke/blood/*diagnosis/*epidemiology/etiology [MESH]


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