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2018 ; 8
(ä): 28
Nephropedia Template TP
gab.com Text
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English Wikipedia
A novel organ preservation solution with efficient clearance of red blood cells
improves kidney transplantation in a canine model
#MMPMID29651333
Wang S
; Gumpper K
; Tan T
; Luo X
; Guo H
; Ming C
; Jiang H
; Fang J
; Du G
; Zhu H
; Ma J
; Chen Z
; Gong N
Cell Biosci
2018[]; 8
(ä): 28
PMID29651333
show ga
Organ preservation solutions are designed to minimize organ damage during
transplantation. A novel preservation solution, WMO-II, was developed to have a
low viscosity and to improve microvasculature perfusion for kidneys. In an
autologous canine transplantation model, kidney function and recovery were
evaluated after organs were flushed and cold-stored with WMO-II or HTK solution,
a perfusate currently approved for clinical use. The average number of red blood
cells remaining in a single glomerulus after flushing with WMO-II was
significantly reduced when compared with HTK solution. Additionally, WMO-II
reduced the number of apoptotic bodies in stored kidneys compared to HTK treated
tissue after 48 h of cold storage by reducing expression of Caspase-9, BiP, Chop,
and Caspase-12. WMO-II solution reduced serum creatinine levels and serum
potassium in kidneys stored for 48 h when compared to HTK perfusion. WMO-II
preserves kidney function as evidenced by the reduction in serum creatinine and
potassium during graft transplantation.