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10.1186/s13578-018-0226-2

http://scihub22266oqcxt.onion/10.1186/s13578-018-0226-2
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suck abstract from ncbi


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pmid29651333
      Cell+Biosci 2018 ; 8 (ä): 28
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  • A novel organ preservation solution with efficient clearance of red blood cells improves kidney transplantation in a canine model #MMPMID29651333
  • Wang S ; Gumpper K ; Tan T ; Luo X ; Guo H ; Ming C ; Jiang H ; Fang J ; Du G ; Zhu H ; Ma J ; Chen Z ; Gong N
  • Cell Biosci 2018[]; 8 (ä): 28 PMID29651333 show ga
  • Organ preservation solutions are designed to minimize organ damage during transplantation. A novel preservation solution, WMO-II, was developed to have a low viscosity and to improve microvasculature perfusion for kidneys. In an autologous canine transplantation model, kidney function and recovery were evaluated after organs were flushed and cold-stored with WMO-II or HTK solution, a perfusate currently approved for clinical use. The average number of red blood cells remaining in a single glomerulus after flushing with WMO-II was significantly reduced when compared with HTK solution. Additionally, WMO-II reduced the number of apoptotic bodies in stored kidneys compared to HTK treated tissue after 48 h of cold storage by reducing expression of Caspase-9, BiP, Chop, and Caspase-12. WMO-II solution reduced serum creatinine levels and serum potassium in kidneys stored for 48 h when compared to HTK perfusion. WMO-II preserves kidney function as evidenced by the reduction in serum creatinine and potassium during graft transplantation.
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