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10.1038/s41598-018-24146-z http://scihub22266oqcxt.onion/10.1038/s41598-018-24146-z C5893623!5893623 !29636552     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29636552 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Rep 2018 ; 8 (1 ): 5779 Nephropedia Template TP {{tp|p=29636552 |t=2018. Calorie restriction is the most reasonable anti-ageing intervention: a meta-analysis of survival curves |pdf=|usr=}}{{29636552 }} gab.com Text Calorie restriction is the most reasonable anti-ageing intervention: a meta-analysis of survival curves JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=29636552 #FOAvip Despite technological advances, the survival records from longevity experiments remain the most indispensable tool in ageing-related research. A variety of interventions, including medications, genetic manipulations and calorie restriction (CR), have been demonstrated to extend the lifespan of several species. Surprisingly, few systematic studies have investigated the differences among these anti-ageing strategies using survival data. Here, we conduct a comprehensive and comparative meta-analysis of numerous published studies on Caenorhabditis elegans and Drosophila. We found that CR and genetic manipulations are generally more effective than medications at extending the total lifespan in both models, and CR can improve the ageing pattern of C. elegans. We further analysed the survival variation for different anti-ageing medications and determined that hypoglycaemic agents and antioxidants are advantageous despite only moderately increasing the overall lifespan; therefore, these two types of medications are promising CR mimetics. Analysis of genetic manipulations also indicated that the genes or pathways that extend lifespan in a healthier pattern are associated with CR. These results suggest that CR or CR mimetics may be the most reasonable and potentially beneficial anti-ageing strategy. Twit Text FOAVip Calorie restriction is the most reasonable anti-ageing intervention: a meta-analysis of survival curves ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=29636552 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29636552 #FOAvip English Wikipedia <ref>{{Cite pmid|29636552 }}</ref> Calorie restriction is the most reasonable anti-ageing intervention: a meta-analysis of survival curves #MMPMID29636552 Liang Y ; Liu C ; Lu M ; Dong Q ; Wang Z ; Wang Z ; Xiong W ; Zhang N ; Zhou J ; Liu Q ; Wang X ; Wang Z Sci Rep 2018[Apr]; 8 (1 ): 5779 PMID29636552 show ga Despite technological advances, the survival records from longevity experiments remain the most indispensable tool in ageing-related research. A variety of interventions, including medications, genetic manipulations and calorie restriction (CR), have been demonstrated to extend the lifespan of several species. Surprisingly, few systematic studies have investigated the differences among these anti-ageing strategies using survival data. Here, we conduct a comprehensive and comparative meta-analysis of numerous published studies on Caenorhabditis elegans and Drosophila. We found that CR and genetic manipulations are generally more effective than medications at extending the total lifespan in both models, and CR can improve the ageing pattern of C. elegans. We further analysed the survival variation for different anti-ageing medications and determined that hypoglycaemic agents and antioxidants are advantageous despite only moderately increasing the overall lifespan; therefore, these two types of medications are promising CR mimetics. Analysis of genetic manipulations also indicated that the genes or pathways that extend lifespan in a healthier pattern are associated with CR. These results suggest that CR or CR mimetics may be the most reasonable and potentially beneficial anti-ageing strategy. |*Caloric Restriction [MESH] |Animals [MESH] |Antioxidants/pharmacology [MESH] |Biomimetics [MESH] |Caenorhabditis elegans/drug effects/physiology [MESH] |Drosophila/drug effects/physiology [MESH] |Hypoglycemic Agents/pharmacology [MESH]Calorie restriction is the most reasonable anti-ageing intervention: a(epmc).pdf DeepDyve Pubget Overpricing