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10.1002/brb3.948 http://scihub22266oqcxt.onion/10.1002/brb3.948 C5893335!5893335!29670828     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 280.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 280.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Brain+Behav 2018 ; 8 (4): ä Nephropedia Template TP {{tp|p=29670828|t=2018. High expression of the HMGB1?TLR4 axis and its downstream signaling factors in patients with Parkinson s disease and the relationship of pathological staging |pdf=|usr=}}{{29670828}} gab.com Text High expression of the HMGB1 TLR4 axis and its downstream signaling factors in patients with Parkinson s disease and the relationship of pathological staging JO: Brain Behav http://www.kidney.de/pget.php?&tw=1&pmid=29670828 #FOAvip Objective: To detect the expression of high?mobility group box protein 1 (HMGB1) and toll?like receptor 4 (TLR4) and their downstream signaling factors?myeloid differentiation factor 88 (MyD88), nuclear factor kappa B (NF??B), and tumor necrosis factor alpha (TNF??)?in the sera of patients with Parkinson's disease (PD) in order to evaluate the relationship of the HMGB1?TLR4 axis with PD development and progression. Methods: The serum HMGB1 and TLR4 protein levels of 120 patients with PD and 100 healthy volunteers were measured using double?antibody sandwich ELISA, and their correlations with PD staging, disease duration, drug treatment effectiveness, and clinical classification were analyzed. In addition, their correlations with the key downstream factors of the HMGB1?TLR4 axis (MyD88, NF??B, and TNF??) were analyzed. Results: HMGB1 and TLR4 expressions were higher in the peripheral blood of patients with PD than in healthy volunteers. PD patients with poor drug treatment outcomes had significantly higher HMGB1 and TLR4 expressions than PD patients with stable drug treatment outcomes. Higher HMGB1 and TLR4 expressions were found in patients at higher PD stages, and patients with >4?year disease duration had significantly higher HMGB1 and TLR4 expressions than patients with <4?year disease duration. No significant difference in HMGB1 and TLR4 expressions was found among patients with tremor?dominant, akinetic?rigid, and mixed subtypes of PD. NF??B and TNF?? expressions were positively correlated with high expression of the HMGB1?TLR4 axis. Conclusion: High expression of the HMGB1?TLR4 axis is closely associated with PD development, progression, drug treatment effectiveness, staging, and disease duration and has great significance for PD diagnosis and treatment. Twit Text FOAVip High expression of the HMGB1 TLR4 axis and its downstream signaling factors in patients with Parkinson s disease and the relationship of pathological staging ????Brain Behav http://www.kidney.de/pget.php?&tw=1&pmid=29670828 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29670828 #FOAvip English Wikipedia <ref>{{Cite pmid|29670828}}</ref> High expression of the HMGB1?TLR4 axis and its downstream signaling factors in patients with Parkinson s disease and the relationship of pathological staging #MMPMID29670828 Yang Y; Han C; Guo L; Guan Q Brain Behav 2018[Apr]; 8 (4): ä PMID29670828show ga Objective: To detect the expression of high?mobility group box protein 1 (HMGB1) and toll?like receptor 4 (TLR4) and their downstream signaling factors?myeloid differentiation factor 88 (MyD88), nuclear factor kappa B (NF??B), and tumor necrosis factor alpha (TNF??)?in the sera of patients with Parkinson's disease (PD) in order to evaluate the relationship of the HMGB1?TLR4 axis with PD development and progression. Methods: The serum HMGB1 and TLR4 protein levels of 120 patients with PD and 100 healthy volunteers were measured using double?antibody sandwich ELISA, and their correlations with PD staging, disease duration, drug treatment effectiveness, and clinical classification were analyzed. In addition, their correlations with the key downstream factors of the HMGB1?TLR4 axis (MyD88, NF??B, and TNF??) were analyzed. Results: HMGB1 and TLR4 expressions were higher in the peripheral blood of patients with PD than in healthy volunteers. PD patients with poor drug treatment outcomes had significantly higher HMGB1 and TLR4 expressions than PD patients with stable drug treatment outcomes. Higher HMGB1 and TLR4 expressions were found in patients at higher PD stages, and patients with >4?year disease duration had significantly higher HMGB1 and TLR4 expressions than patients with <4?year disease duration. No significant difference in HMGB1 and TLR4 expressions was found among patients with tremor?dominant, akinetic?rigid, and mixed subtypes of PD. NF??B and TNF?? expressions were positively correlated with high expression of the HMGB1?TLR4 axis. Conclusion: High expression of the HMGB1?TLR4 axis is closely associated with PD development, progression, drug treatment effectiveness, staging, and disease duration and has great significance for PD diagnosis and treatment. äHigh expression of the HMGB1?TLR4 axis and its downstream signaling fa(epmc).pdf DeepDyve Pubget Overpricing