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10.18632/oncotarget.24631 http://scihub22266oqcxt.onion/10.18632/oncotarget.24631 C5893241!5893241!29662646     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncotarget 2018 ; 9 (23): 16297-310 Nephropedia Template TP {{tp|p=29662646|t=2018. VHL status regulates transforming growth factor-? signaling pathways in renal cell carcinoma |pdf=|usr=}}{{29662646}} gab.com Text VHL status regulates transforming growth factor- signaling pathways in renal cell carcinoma JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=29662646 #FOAvip To evaluate the role of pVHL in the regulation of TGF-? signaling pathways in clear cell renal cell carcinoma (ccRCC) as well as in non-ccRCC; the expression of pVHL, and the TGF-? pathway components and their association with clinicopathological parameters and patient?s survival were explored. Tissue samples from 143 ccRCC and 58 non-ccRCC patients were examined by immunoblot. ccRCC cell lines were utilized for mechanistic in-vitro studies. Expression levels of pVHL were significantly lower in ccRCC compared with non-ccRCC. Non-ccRCC and ccRCC pVHL-High expressed similar levels of pVHL. Expression of the TGF-? type I receptor (ALK5) and intra-cellular domain were significantly higher in ccRCC compared with non-ccRCC. In non-ccRCC, expressions of ALK5-FL, ALK5-ICD, pSMAD2/3, and PAI-1 had no association with clinicopathological parameters and survival. In ccRCC pVHL-Low, ALK5-FL, ALK5-ICD, pSMAD2/3, and PAI-1 were significantly related with tumor stage, size, and survival. In ccRCC pVHL-High, the expression of PAI-1 was associated with stage and survival. In-vitro studies revealed that pVHL interacted with ALK5 to downregulate its expression through K48-linked poly-ubiquitination and proteasomal degradation, thus negatively controlling TGF-? induced cancer cell invasiveness. The pVHL status controls the ALK5 and can thereby regulate the TGF-? pathway, aggressiveness of tumors, and survival of the ccRCC and non-ccRCC patients. Twit Text FOAVip VHL status regulates transforming growth factor- signaling pathways in renal cell carcinoma ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=29662646 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29662646 #FOAvip English Wikipedia <ref>{{Cite pmid|29662646}}</ref> VHL status regulates transforming growth factor-? signaling pathways in renal cell carcinoma #MMPMID29662646 Mallikarjuna P; Sitaram RT; Landström M; Ljungberg B Oncotarget 2018[Mar]; 9 (23): 16297-310 PMID29662646show ga To evaluate the role of pVHL in the regulation of TGF-? signaling pathways in clear cell renal cell carcinoma (ccRCC) as well as in non-ccRCC; the expression of pVHL, and the TGF-? pathway components and their association with clinicopathological parameters and patient?s survival were explored. Tissue samples from 143 ccRCC and 58 non-ccRCC patients were examined by immunoblot. ccRCC cell lines were utilized for mechanistic in-vitro studies. Expression levels of pVHL were significantly lower in ccRCC compared with non-ccRCC. Non-ccRCC and ccRCC pVHL-High expressed similar levels of pVHL. Expression of the TGF-? type I receptor (ALK5) and intra-cellular domain were significantly higher in ccRCC compared with non-ccRCC. In non-ccRCC, expressions of ALK5-FL, ALK5-ICD, pSMAD2/3, and PAI-1 had no association with clinicopathological parameters and survival. In ccRCC pVHL-Low, ALK5-FL, ALK5-ICD, pSMAD2/3, and PAI-1 were significantly related with tumor stage, size, and survival. In ccRCC pVHL-High, the expression of PAI-1 was associated with stage and survival. In-vitro studies revealed that pVHL interacted with ALK5 to downregulate its expression through K48-linked poly-ubiquitination and proteasomal degradation, thus negatively controlling TGF-? induced cancer cell invasiveness. The pVHL status controls the ALK5 and can thereby regulate the TGF-? pathway, aggressiveness of tumors, and survival of the ccRCC and non-ccRCC patients. äVHL status regulates transforming growth factor-? signaling pathways i(epmc).pdf DeepDyve Pubget Overpricing